Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313355024> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4313355024 endingPage "43.1" @default.
- W4313355024 startingPage "43.1" @default.
- W4313355024 abstract "Abstract An estimated 1 billion people worldwide have deficient or insufficient levels of vitamin D (VitD), while roughly 25% of individuals in the US are reported to have inadequate VitD levels. Considerable evidence indicates that VitD deficiency is associated with an increased risk of cardiovascular disease (CVD), yet it remains unclear whether low VitD is simply a biomarker of CVD or has a true pathologic role. The role of VitD deficiency in the pathogenesis of inflammatory myocarditis is unknown- a disease that is higher in men. We found that only 20% of myocarditis patients had low VitD levels. When we examined VitD receptor (VDR) deficient mice in a model of viral myocarditis, we found that VDR decreased myocarditis in females (p=0.007) but increased inflammation in males (p=0.006). Examination of cytokines in the heart found that VDR-/- male mice had significantly reduced IFN-γ and IL-1β and increased IL-17A, but no significant differences were found in females. Comparison of microarray data during myocarditis to published VitD response element genes revealed around 200 genes associated with proinflammatory (e.g. caspase-1) and profibrotic (e.g. TGF-β1, MMP) responses were increased in WT male mice, which was confirmed by qRT-PCR in VDR-/- mice. Our data confirms that VitD through the VDR promotes myocardial inflammation in males, providing a mechanism for how low VitD levels in men increase myocarditis. This work was funded by NIH R01 HL087033 and HL111938." @default.
- W4313355024 created "2023-01-06" @default.
- W4313355024 creator A5018022438 @default.
- W4313355024 creator A5039857347 @default.
- W4313355024 creator A5041200138 @default.
- W4313355024 creator A5050860766 @default.
- W4313355024 creator A5059554092 @default.
- W4313355024 creator A5061773218 @default.
- W4313355024 creator A5072668391 @default.
- W4313355024 creator A5082705897 @default.
- W4313355024 date "2013-05-01" @default.
- W4313355024 modified "2023-09-27" @default.
- W4313355024 title "Sex differences in the effect of vitamin D on inflammatory heart disease: protective in women but damaging in men (P3069)" @default.
- W4313355024 doi "https://doi.org/10.4049/jimmunol.190.supp.43.1" @default.
- W4313355024 hasPublicationYear "2013" @default.
- W4313355024 type Work @default.
- W4313355024 citedByCount "0" @default.
- W4313355024 crossrefType "journal-article" @default.
- W4313355024 hasAuthorship W4313355024A5018022438 @default.
- W4313355024 hasAuthorship W4313355024A5039857347 @default.
- W4313355024 hasAuthorship W4313355024A5041200138 @default.
- W4313355024 hasAuthorship W4313355024A5050860766 @default.
- W4313355024 hasAuthorship W4313355024A5059554092 @default.
- W4313355024 hasAuthorship W4313355024A5061773218 @default.
- W4313355024 hasAuthorship W4313355024A5072668391 @default.
- W4313355024 hasAuthorship W4313355024A5082705897 @default.
- W4313355024 hasConcept C124490489 @default.
- W4313355024 hasConcept C126322002 @default.
- W4313355024 hasConcept C134018914 @default.
- W4313355024 hasConcept C164027704 @default.
- W4313355024 hasConcept C179639408 @default.
- W4313355024 hasConcept C203014093 @default.
- W4313355024 hasConcept C2776914184 @default.
- W4313355024 hasConcept C2779134260 @default.
- W4313355024 hasConcept C2779740938 @default.
- W4313355024 hasConcept C2780875844 @default.
- W4313355024 hasConcept C2780942790 @default.
- W4313355024 hasConcept C2781197716 @default.
- W4313355024 hasConcept C54355233 @default.
- W4313355024 hasConcept C71924100 @default.
- W4313355024 hasConcept C86803240 @default.
- W4313355024 hasConceptScore W4313355024C124490489 @default.
- W4313355024 hasConceptScore W4313355024C126322002 @default.
- W4313355024 hasConceptScore W4313355024C134018914 @default.
- W4313355024 hasConceptScore W4313355024C164027704 @default.
- W4313355024 hasConceptScore W4313355024C179639408 @default.
- W4313355024 hasConceptScore W4313355024C203014093 @default.
- W4313355024 hasConceptScore W4313355024C2776914184 @default.
- W4313355024 hasConceptScore W4313355024C2779134260 @default.
- W4313355024 hasConceptScore W4313355024C2779740938 @default.
- W4313355024 hasConceptScore W4313355024C2780875844 @default.
- W4313355024 hasConceptScore W4313355024C2780942790 @default.
- W4313355024 hasConceptScore W4313355024C2781197716 @default.
- W4313355024 hasConceptScore W4313355024C54355233 @default.
- W4313355024 hasConceptScore W4313355024C71924100 @default.
- W4313355024 hasConceptScore W4313355024C86803240 @default.
- W4313355024 hasIssue "1_Supplement" @default.
- W4313355024 hasLocation W43133550241 @default.
- W4313355024 hasOpenAccess W4313355024 @default.
- W4313355024 hasPrimaryLocation W43133550241 @default.
- W4313355024 hasRelatedWork W1824985903 @default.
- W4313355024 hasRelatedWork W1975759361 @default.
- W4313355024 hasRelatedWork W2009745211 @default.
- W4313355024 hasRelatedWork W2061638913 @default.
- W4313355024 hasRelatedWork W2071103727 @default.
- W4313355024 hasRelatedWork W2141069430 @default.
- W4313355024 hasRelatedWork W2147487489 @default.
- W4313355024 hasRelatedWork W2918820351 @default.
- W4313355024 hasRelatedWork W4229053620 @default.
- W4313355024 hasRelatedWork W4313382057 @default.
- W4313355024 hasVolume "190" @default.
- W4313355024 isParatext "false" @default.
- W4313355024 isRetracted "false" @default.
- W4313355024 workType "article" @default.