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- W4313355044 abstract "Abstract The Wnt/β-catenin pathway has been known to play a role in induction of immune tolerance, but its role in the induction and maintenance of NKT cell anergy is unknown. We found that activation of the Wnt pathway(s) in the liver microenvironment is important for induction of NKT cell anergy. We identified Glycolipid α-GalCer treatment of mice induced the expression of wnt3a and wnt5a in the liver, and subsequently resulted in a liver microenvironment that induced NKT cell anergy to α-GalCer restimulation. Mice treated with PGE(2) associated with intestinal mucus-derived exosome-like nanoparticles (IDEN) induced NKT cell anergy. PGE2 treatment leads to activation of the Wnt/β-catenin pathway by inactivation of GSK-3β of NKT cells. Pro-inflammatory conditions enhanced the migration of IDEN to the liver where both α-GalCer and PGE2 induced activation of the Wnt pathway thereby inducing NKT anergy in response to subsequent α-GalCer stimulation. IDEN-associated PGE2 also induces NKT cell anergy through modification of the ability of DCs to induce IL-12 and IFN-β in the context of both glycolipid presentation and TLR-mediated pathways. These findings demonstrate that IDEN associated PGE2 serves as an endogenous immune modulator between the liver and intestines and maintains liver NKT cell homeostasis and this finding has implications for development of NKT cell-based immunotherapies." @default.
- W4313355044 created "2023-01-06" @default.
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- W4313355044 date "2013-05-01" @default.
- W4313355044 modified "2023-10-18" @default.
- W4313355044 title "Intestinal mucus-derived nanoparticles carry prostaglandin E2 and suppress liver inflammation through Wnt/β-catenin signaling (P3294)" @default.
- W4313355044 doi "https://doi.org/10.4049/jimmunol.190.supp.136.29" @default.
- W4313355044 hasPublicationYear "2013" @default.
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