Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313355307> ?p ?o ?g. }
- W4313355307 endingPage "121306" @default.
- W4313355307 startingPage "121306" @default.
- W4313355307 abstract "Female sub-fertility, a prominent complication due to Type 1 diabetes (T1D), is generally attributed to disturbances in menstrual cycles and/or ovarian defects/disorders. T1D women, however, are high in oxidative stress, although the impact of the same on their reproduction and associated events remains unknown. Therefore, we assessed the repercussions of elevated oxidative stress on the sperm fate (storage/utilization) in the reproductive tract milieu of T1D females and their fertility using the Drosophila T1D model (Df[dilp1–5]), which lacks insulin-like peptides and displays reduced female fertility. We mated Df[dilp1–5] females to normal males and thereafter examined sperm storage and/or utilization in conjunction with oxidative stress parameters in mated Df[dilp1–5] females at different time points. Also, the impact of antioxidant (Amla or Vitamin C) supplementation on the above oxidative stress parameters in Df[dilp1–5] females and the consequences on their sperm and fertility levels were examined. Df[dilp1–5] females showed elevated oxidative stress parameters and a few of their reproductive tract proteins are oxidatively modified. Also, these females stored significantly fewer sperm and also did not utilize sperm as efficiently as their controls. Surprisingly, amelioration of the oxidative stress in Df[dilp1–5] females' milieu through antioxidant (Amla or vitamin C) supplementation enhanced sperm storage and improved fertility. Hyperglycemia coupled with elevated oxidative stress within the female reproductive tract environment affects the sperm fate, thereby reducing female fertility in T1D. In addition, these findings suggest that antioxidant supplementation may substantially aid in the mitigation of sub-fertility in T1D females." @default.
- W4313355307 created "2023-01-06" @default.
- W4313355307 creator A5006914372 @default.
- W4313355307 creator A5032083032 @default.
- W4313355307 creator A5065090116 @default.
- W4313355307 date "2023-01-01" @default.
- W4313355307 modified "2023-09-29" @default.
- W4313355307 title "Altered sperm fate in the reproductive tract milieu due to oxidative stress leads to sub-fertility in type 1 diabetes females: A Drosophila-based study" @default.
- W4313355307 cites W107456955 @default.
- W4313355307 cites W145770872 @default.
- W4313355307 cites W1526628849 @default.
- W4313355307 cites W1537621649 @default.
- W4313355307 cites W1567614586 @default.
- W4313355307 cites W1581414347 @default.
- W4313355307 cites W1966559953 @default.
- W4313355307 cites W1966936409 @default.
- W4313355307 cites W1968138979 @default.
- W4313355307 cites W1978110501 @default.
- W4313355307 cites W1980241059 @default.
- W4313355307 cites W1983271950 @default.
- W4313355307 cites W1983310681 @default.
- W4313355307 cites W1984140215 @default.
- W4313355307 cites W1990933433 @default.
- W4313355307 cites W1992795326 @default.
- W4313355307 cites W1994790223 @default.
- W4313355307 cites W1995688623 @default.
- W4313355307 cites W1996611867 @default.
- W4313355307 cites W2005818470 @default.
- W4313355307 cites W2008199204 @default.
- W4313355307 cites W2009801880 @default.
- W4313355307 cites W2011683287 @default.
- W4313355307 cites W2011910455 @default.
- W4313355307 cites W2015550884 @default.
- W4313355307 cites W2019287011 @default.
- W4313355307 cites W2020046215 @default.
- W4313355307 cites W2027478328 @default.
- W4313355307 cites W2030511738 @default.
- W4313355307 cites W2031976997 @default.
- W4313355307 cites W2032090094 @default.
- W4313355307 cites W2032157788 @default.
- W4313355307 cites W2035844729 @default.
- W4313355307 cites W2036615909 @default.
- W4313355307 cites W2038474622 @default.
- W4313355307 cites W2044406911 @default.
- W4313355307 cites W2048915770 @default.
- W4313355307 cites W2051478210 @default.
- W4313355307 cites W2051980238 @default.
- W4313355307 cites W2053666915 @default.
- W4313355307 cites W2054162066 @default.
- W4313355307 cites W2064003795 @default.
- W4313355307 cites W2065100064 @default.
- W4313355307 cites W2069797199 @default.
- W4313355307 cites W2071367254 @default.
- W4313355307 cites W2079189585 @default.
- W4313355307 cites W2105731956 @default.
- W4313355307 cites W2106375653 @default.
- W4313355307 cites W2108762011 @default.
- W4313355307 cites W2110165715 @default.
- W4313355307 cites W2112878750 @default.
- W4313355307 cites W2130801840 @default.
- W4313355307 cites W2132073332 @default.
- W4313355307 cites W2140906896 @default.
- W4313355307 cites W2147545348 @default.
- W4313355307 cites W2148392079 @default.
- W4313355307 cites W2153344238 @default.
- W4313355307 cites W2154344325 @default.
- W4313355307 cites W2160874447 @default.
- W4313355307 cites W2163578413 @default.
- W4313355307 cites W2169990014 @default.
- W4313355307 cites W2170863564 @default.
- W4313355307 cites W2171553260 @default.
- W4313355307 cites W2326648248 @default.
- W4313355307 cites W2819037259 @default.
- W4313355307 cites W2936446594 @default.
- W4313355307 cites W2957253452 @default.
- W4313355307 cites W2964136162 @default.
- W4313355307 cites W908481357 @default.
- W4313355307 doi "https://doi.org/10.1016/j.lfs.2022.121306" @default.
- W4313355307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36543282" @default.
- W4313355307 hasPublicationYear "2023" @default.
- W4313355307 type Work @default.
- W4313355307 citedByCount "0" @default.
- W4313355307 crossrefType "journal-article" @default.
- W4313355307 hasAuthorship W4313355307A5006914372 @default.
- W4313355307 hasAuthorship W4313355307A5032083032 @default.
- W4313355307 hasAuthorship W4313355307A5065090116 @default.
- W4313355307 hasConcept C126322002 @default.
- W4313355307 hasConcept C134018914 @default.
- W4313355307 hasConcept C16685009 @default.
- W4313355307 hasConcept C2776151105 @default.
- W4313355307 hasConcept C2777551382 @default.
- W4313355307 hasConcept C2778004101 @default.
- W4313355307 hasConcept C2780022331 @default.
- W4313355307 hasConcept C2781087480 @default.
- W4313355307 hasConcept C2908647359 @default.
- W4313355307 hasConcept C42407357 @default.
- W4313355307 hasConcept C518429986 @default.
- W4313355307 hasConcept C54355233 @default.