Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313355593> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4313355593 endingPage "99.3" @default.
- W4313355593 startingPage "99.3" @default.
- W4313355593 abstract "Abstract Gamma-IFN inducible lysosomal thiol reductase (GILT) is currently the only identified thiol reductase that has optimal activity at acidic pH and localizes to lysosomes. GILT is constitutively expressed in antigen presenting cells (APC), is inducible by gamma-IFN, and participates in Ag processing by catalyzing the reduction of disulfide (S-S) bonds, thus facilitating the unfolding of native S-S bond containing Ag for further processing. Previous studies reported that T cells from GILT knock-out (GILT−/−) mice mounted a significantly reduced proliferative response to S-S containing protein Ag in vitro, GILT−/− APCs have a selective deficiency in presentation of some cysteine-containing epitopes from hen egg lysozyme, and GILT−/− mice exhibited a change in the pathogenic epitope of experimental autoimmune encephalomyelitis. Using MS/MS analysis, we identified a set of unique GILT-dependent, MHC-II associated-peptides in WT vs. GILT−/− mice, which we then validate by generating T cells specific to a unique GILT-dependent epitope from GILT−/− but not WT B6 mice. Our data suggests that GILT−/− mice are deficient in the generation of specific T cell epitopes due to a loss in GILT activity. This is consistent with our another on-going study where we find that GILT−/− mice failed to generate an Ab response to insulin due to inefficient processing of an S-S containing epitope in insulin. We hypothesize that in GILT−/− mice, GILT inactivation causes a change in the epitope repertoire that may lead to survival (escape from negative selection) of the T cells specific to GILT dependent epitopes in the thymus. The presence of these auto-reactive T cells might have implications for autoimmunity and autoimmune diseases." @default.
- W4313355593 created "2023-01-06" @default.
- W4313355593 creator A5049873458 @default.
- W4313355593 creator A5057262156 @default.
- W4313355593 creator A5059352135 @default.
- W4313355593 creator A5062600217 @default.
- W4313355593 creator A5081134319 @default.
- W4313355593 date "2018-05-01" @default.
- W4313355593 modified "2023-09-27" @default.
- W4313355593 title "Identification of a gamma IFN inducible lysosomal thiol reductase (GILT)-dependent MHC-II associated epitope that induces T cell responses in GILT−/− mice" @default.
- W4313355593 doi "https://doi.org/10.4049/jimmunol.200.supp.99.3" @default.
- W4313355593 hasPublicationYear "2018" @default.
- W4313355593 type Work @default.
- W4313355593 citedByCount "0" @default.
- W4313355593 crossrefType "journal-article" @default.
- W4313355593 hasAuthorship W4313355593A5049873458 @default.
- W4313355593 hasAuthorship W4313355593A5057262156 @default.
- W4313355593 hasAuthorship W4313355593A5059352135 @default.
- W4313355593 hasAuthorship W4313355593A5062600217 @default.
- W4313355593 hasAuthorship W4313355593A5081134319 @default.
- W4313355593 hasConcept C147483822 @default.
- W4313355593 hasConcept C153911025 @default.
- W4313355593 hasConcept C181199279 @default.
- W4313355593 hasConcept C185592680 @default.
- W4313355593 hasConcept C195616568 @default.
- W4313355593 hasConcept C203014093 @default.
- W4313355593 hasConcept C207936829 @default.
- W4313355593 hasConcept C2776090121 @default.
- W4313355593 hasConcept C2779201268 @default.
- W4313355593 hasConcept C55493867 @default.
- W4313355593 hasConcept C86803240 @default.
- W4313355593 hasConcept C8891405 @default.
- W4313355593 hasConcept C95444343 @default.
- W4313355593 hasConceptScore W4313355593C147483822 @default.
- W4313355593 hasConceptScore W4313355593C153911025 @default.
- W4313355593 hasConceptScore W4313355593C181199279 @default.
- W4313355593 hasConceptScore W4313355593C185592680 @default.
- W4313355593 hasConceptScore W4313355593C195616568 @default.
- W4313355593 hasConceptScore W4313355593C203014093 @default.
- W4313355593 hasConceptScore W4313355593C207936829 @default.
- W4313355593 hasConceptScore W4313355593C2776090121 @default.
- W4313355593 hasConceptScore W4313355593C2779201268 @default.
- W4313355593 hasConceptScore W4313355593C55493867 @default.
- W4313355593 hasConceptScore W4313355593C86803240 @default.
- W4313355593 hasConceptScore W4313355593C8891405 @default.
- W4313355593 hasConceptScore W4313355593C95444343 @default.
- W4313355593 hasIssue "1_Supplement" @default.
- W4313355593 hasLocation W43133555931 @default.
- W4313355593 hasOpenAccess W4313355593 @default.
- W4313355593 hasPrimaryLocation W43133555931 @default.
- W4313355593 hasRelatedWork W1847656527 @default.
- W4313355593 hasRelatedWork W2039544316 @default.
- W4313355593 hasRelatedWork W2052321337 @default.
- W4313355593 hasRelatedWork W2059853480 @default.
- W4313355593 hasRelatedWork W2098039852 @default.
- W4313355593 hasRelatedWork W2789620378 @default.
- W4313355593 hasRelatedWork W2795094969 @default.
- W4313355593 hasRelatedWork W3036327081 @default.
- W4313355593 hasRelatedWork W4313380694 @default.
- W4313355593 hasRelatedWork W4313383065 @default.
- W4313355593 hasVolume "200" @default.
- W4313355593 isParatext "false" @default.
- W4313355593 isRetracted "false" @default.
- W4313355593 workType "article" @default.