Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313355819> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4313355819 endingPage "141.8" @default.
- W4313355819 startingPage "141.8" @default.
- W4313355819 abstract "Abstract The nature of regulatory T cells (Tregs) in cancer is ambivalent. In Colon Cancer (CC) patients and animal models of CC, we previously described a distinct subset of Tregs that suppresses anti-tumor effector T cell functions but simultaneously maintains inflammation. These Tregs co-express the Th17 lineage transcription factor RORγt along with Foxp3. Moreover, we causatively linked the pro-inflammatory skewing of T cells to Wnt/β-catenin-signaling. To elucidate how Wnt/β-catenin signaling orchestrates the induction of pathologic properties in Tregs we analyzed inflammatory bowel disease (IBD) patients. As IBD can progress to CC, this disease presents a unique platform to study the mechanisms underlying the emergence of RORγt+/Foxp3+Tregs. Indeed, in a sub-population of IBD patients we were able to detect RORγt+/Foxp3+Tregs, expressing high levels of β-catenin in the patients’ blood and tissue. To further establish that activated Wnt/β-catenin signaling is responsible for the pro-inflammatory skewing of Foxp3+ Tregs we over-expressed β-catenin Treg-specifically in a conditional Foxp3-Cre driven mouse model. Mice expressing constitutively active β-catenin in Tregs show striking X-linked immune pathology. Males die 4 weeks after birth of a severe scurfy-like phenotype. Although their Tregs are highly activated, they fail to suppress the proliferation of effector T cells. In heterozygous Foxp3-Cre mice, representing natural chimeras harboring wildtype and β-catenin over-expressing Tregs, the relative fitness of genetically altered Tregs is decreased. By further elucidating how Wnt/β-catenin signaling mediates the pathogenic conversion of Tregs, we hope to reveal novel targets for cancer immuno-therapy." @default.
- W4313355819 created "2023-01-06" @default.
- W4313355819 creator A5019333026 @default.
- W4313355819 creator A5042689717 @default.
- W4313355819 creator A5059143816 @default.
- W4313355819 creator A5086035685 @default.
- W4313355819 date "2017-05-01" @default.
- W4313355819 modified "2023-09-23" @default.
- W4313355819 title "Pathogenic conversion of RORγt+/Foxp3+ double positive regulatory T cells involves β-catenin up-regulation" @default.
- W4313355819 doi "https://doi.org/10.4049/jimmunol.198.supp.141.8" @default.
- W4313355819 hasPublicationYear "2017" @default.
- W4313355819 type Work @default.
- W4313355819 citedByCount "0" @default.
- W4313355819 crossrefType "journal-article" @default.
- W4313355819 hasAuthorship W4313355819A5019333026 @default.
- W4313355819 hasAuthorship W4313355819A5042689717 @default.
- W4313355819 hasAuthorship W4313355819A5059143816 @default.
- W4313355819 hasAuthorship W4313355819A5086035685 @default.
- W4313355819 hasConcept C137620995 @default.
- W4313355819 hasConcept C203014093 @default.
- W4313355819 hasConcept C2776914184 @default.
- W4313355819 hasConcept C2779727006 @default.
- W4313355819 hasConcept C2908647359 @default.
- W4313355819 hasConcept C502942594 @default.
- W4313355819 hasConcept C62478195 @default.
- W4313355819 hasConcept C71924100 @default.
- W4313355819 hasConcept C74737994 @default.
- W4313355819 hasConcept C86803240 @default.
- W4313355819 hasConcept C8891405 @default.
- W4313355819 hasConcept C95444343 @default.
- W4313355819 hasConcept C99454951 @default.
- W4313355819 hasConceptScore W4313355819C137620995 @default.
- W4313355819 hasConceptScore W4313355819C203014093 @default.
- W4313355819 hasConceptScore W4313355819C2776914184 @default.
- W4313355819 hasConceptScore W4313355819C2779727006 @default.
- W4313355819 hasConceptScore W4313355819C2908647359 @default.
- W4313355819 hasConceptScore W4313355819C502942594 @default.
- W4313355819 hasConceptScore W4313355819C62478195 @default.
- W4313355819 hasConceptScore W4313355819C71924100 @default.
- W4313355819 hasConceptScore W4313355819C74737994 @default.
- W4313355819 hasConceptScore W4313355819C86803240 @default.
- W4313355819 hasConceptScore W4313355819C8891405 @default.
- W4313355819 hasConceptScore W4313355819C95444343 @default.
- W4313355819 hasConceptScore W4313355819C99454951 @default.
- W4313355819 hasIssue "1_Supplement" @default.
- W4313355819 hasLocation W43133558191 @default.
- W4313355819 hasOpenAccess W4313355819 @default.
- W4313355819 hasPrimaryLocation W43133558191 @default.
- W4313355819 hasRelatedWork W1557621914 @default.
- W4313355819 hasRelatedWork W1997714882 @default.
- W4313355819 hasRelatedWork W2004776159 @default.
- W4313355819 hasRelatedWork W2253495375 @default.
- W4313355819 hasRelatedWork W2370215344 @default.
- W4313355819 hasRelatedWork W2382776397 @default.
- W4313355819 hasRelatedWork W2553004139 @default.
- W4313355819 hasRelatedWork W2789823008 @default.
- W4313355819 hasRelatedWork W3018986011 @default.
- W4313355819 hasRelatedWork W3136031961 @default.
- W4313355819 hasVolume "198" @default.
- W4313355819 isParatext "false" @default.
- W4313355819 isRetracted "false" @default.
- W4313355819 workType "article" @default.