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- W4313355833 abstract "Abstract Self-reactive T cells play a central role in Multiple Sclerosis (MS) and invade the central nervous system (CNS) to drive neurological damage. To enter tissues, T cells extravasate through the vascular endothelial cell wall via a process known as transendothelial migration (TEM). While many of the adhesion molecules and chemokine signaling pathways required for TEM are well characterized, little is known about how downstream cytoskeletal effectors mediate the mechanical forces and shape changes needed for T cell TEM. Mouse Diaphanous Homolog 1 (mDia1) is a terminal cytoskeletal effector involved directly in actin network remodeling. It has been associated with the formation of membrane protrusions that likely function in migration and cell-cell interactions and is highly expressed by activated T cells. The goal of our study was to examine the role of mDia1 in T cell extravasation into the CNS and subsequent induction of neuroinflammation. mDia1 knock-out (KO) mice were partially protected from Experimental Autoimmune Encephalomyelitis (EAE), a mouse model of MS. mDia1 deficient ex-vivo activated auto-reactive T cells displayed similar activation kinetics compared to control T cells. However, when these activated mDia1 deficient T cells were transferred into wild-type mice, they were impaired in their ability to induce EAE. In vitro time-lapse microscopy data suggest that mDia1 deficient T cells have a reduced ability to complete TEM across brain endothelium. This defect may explain the reduced ability of mDia1 deficient T cells to induce EAE. Collectively our data suggest that mDia1 may be a promising therapeutic target for regulating T cell trafficking in MS." @default.
- W4313355833 created "2023-01-06" @default.
- W4313355833 creator A5048836814 @default.
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- W4313355833 date "2017-05-01" @default.
- W4313355833 modified "2023-09-26" @default.
- W4313355833 title "mDia1 promotes T cell extravasation and enables induction of Experimental Autoimmune Encephalitis" @default.
- W4313355833 doi "https://doi.org/10.4049/jimmunol.198.supp.143.13" @default.
- W4313355833 hasPublicationYear "2017" @default.
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