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- W4313355878 abstract "Abstract Our laboratory has identified a distinct subset of CD11c+ T-bet+ IgM memory B cells during ehrlichial infection in mice. These cells are likely closely related to phenotypically similar B cells that have been described in a range of other conditions, including hepatitis, AIDs, malaria, SLE, and age-related autoimmunity. In order to identify novel functions of CD11c+ T-bet+ IgM memory B cells, we performed RNAseq analysis. The cells were purified from infected mice on day 30 post-infection, and were compared to CD11c-negative CD19+ B cells isolated from the same mice. The CD11c+ B cells exhibited a distinct transcriptomic profile, compared to the CD11c-negative B cells, as over 900 genes were differentially regulated. Differentially-expressed genes included those encoding for integrins, Fc receptors, transcription factors, complement and receptors involved in innate immunity. Differentially-expressed complement-related genes included those encoding for the C1q complex, properdin, and complement factor B, which were all upregulated. Other genes that were upregulated included those encoding the adenosine receptor Adora2a, Bcl-6, which encodes a transcription factor required for GC B cells and the B cell inhibitory FcR, Fcgr2b. These data open new avenues of exploration of CD11c+ T-bet+ B cell function, and will lead to a better understanding of the role of these novel B cells in human health and disease." @default.
- W4313355878 created "2023-01-06" @default.
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- W4313355878 date "2017-05-01" @default.
- W4313355878 modified "2023-09-27" @default.
- W4313355878 title "Novel functions CD11c+ IgM+ memory B cells suggested from transcriptome analysis" @default.
- W4313355878 doi "https://doi.org/10.4049/jimmunol.198.supp.136.4" @default.
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