Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313355904> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W4313355904 endingPage "81.28" @default.
- W4313355904 startingPage "81.28" @default.
- W4313355904 abstract "Abstract The human genome contains a vast number of enzymes that lack functional annotation. As a result, our basic understanding of enzymatic pathways that underlie human physiology and pathology remains largely incomplete. Molecular profiling technologies have emerged as an unbiased means to globally examine the biochemical makeup of cells and tissues and identify genes and proteins associated with pathophysiological states. In contrast, global methods for the functional characterization of enzymatic pathways in native biological systems are still lacking. I will describe our efforts to integrate activity-based protein profiling (ABPP) with functional proteomic/metabolomics methods to map novel bioactive lipid networks involved in inflammation. I will describe the development of the first selective and in vivo-active small-molecule inhibitors for the 2-arachidonoylglycerol (2-AG) biosynthetic enzyme, diacylglycerol lipase-beta (DAGLB), along with paired negative-control and tailored activity-based probes for the functional analysis of DAGLB in living systems. We utilize our newly developed chemical probes to discover and show that DAGLB inactivation lowers 2-AG production in mouse peritoneal macrophages, as well as arachidonic acid and eicosanoids in a manner that is distinct and complementary to cytosolic phospholipase-A2. A corresponding reduction in lipopolysaccharide (LPS)-induced TNF-alpha release was observed, indicating that DAGLB serves as a key metabolic hub within a lipid signaling network that regulates proinflammatory responses in macrophages. We will present recent findings that identify DAGLB as a promising anti-inflammatory target for treatment of inflammatory and neuropathic pain." @default.
- W4313355904 created "2023-01-06" @default.
- W4313355904 creator A5052558878 @default.
- W4313355904 date "2017-05-01" @default.
- W4313355904 modified "2023-09-25" @default.
- W4313355904 title "New Lipid Metabolic Targets for Treatment of Inflammation" @default.
- W4313355904 doi "https://doi.org/10.4049/jimmunol.198.supp.81.28" @default.
- W4313355904 hasPublicationYear "2017" @default.
- W4313355904 type Work @default.
- W4313355904 citedByCount "2" @default.
- W4313355904 countsByYear W43133559042021 @default.
- W4313355904 crossrefType "journal-article" @default.
- W4313355904 hasAuthorship W4313355904A5052558878 @default.
- W4313355904 hasConcept C164027704 @default.
- W4313355904 hasConcept C180899940 @default.
- W4313355904 hasConcept C181199279 @default.
- W4313355904 hasConcept C195794163 @default.
- W4313355904 hasConcept C203014093 @default.
- W4313355904 hasConcept C2776551241 @default.
- W4313355904 hasConcept C2776914184 @default.
- W4313355904 hasConcept C2778078955 @default.
- W4313355904 hasConcept C36020004 @default.
- W4313355904 hasConcept C55493867 @default.
- W4313355904 hasConcept C58017582 @default.
- W4313355904 hasConcept C70721500 @default.
- W4313355904 hasConcept C86803240 @default.
- W4313355904 hasConcept C95444343 @default.
- W4313355904 hasConceptScore W4313355904C164027704 @default.
- W4313355904 hasConceptScore W4313355904C180899940 @default.
- W4313355904 hasConceptScore W4313355904C181199279 @default.
- W4313355904 hasConceptScore W4313355904C195794163 @default.
- W4313355904 hasConceptScore W4313355904C203014093 @default.
- W4313355904 hasConceptScore W4313355904C2776551241 @default.
- W4313355904 hasConceptScore W4313355904C2776914184 @default.
- W4313355904 hasConceptScore W4313355904C2778078955 @default.
- W4313355904 hasConceptScore W4313355904C36020004 @default.
- W4313355904 hasConceptScore W4313355904C55493867 @default.
- W4313355904 hasConceptScore W4313355904C58017582 @default.
- W4313355904 hasConceptScore W4313355904C70721500 @default.
- W4313355904 hasConceptScore W4313355904C86803240 @default.
- W4313355904 hasConceptScore W4313355904C95444343 @default.
- W4313355904 hasIssue "1_Supplement" @default.
- W4313355904 hasLocation W43133559041 @default.
- W4313355904 hasOpenAccess W4313355904 @default.
- W4313355904 hasPrimaryLocation W43133559041 @default.
- W4313355904 hasRelatedWork W131513067 @default.
- W4313355904 hasRelatedWork W1508067565 @default.
- W4313355904 hasRelatedWork W2115477213 @default.
- W4313355904 hasRelatedWork W2120919525 @default.
- W4313355904 hasRelatedWork W2161169364 @default.
- W4313355904 hasRelatedWork W2197416409 @default.
- W4313355904 hasRelatedWork W2408898930 @default.
- W4313355904 hasRelatedWork W3019086109 @default.
- W4313355904 hasRelatedWork W3149647199 @default.
- W4313355904 hasRelatedWork W4244311005 @default.
- W4313355904 hasVolume "198" @default.
- W4313355904 isParatext "false" @default.
- W4313355904 isRetracted "false" @default.
- W4313355904 workType "article" @default.