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- W4313355910 abstract "Abstract T lymphocytes require two signals for appropriate activation – signal one is obtained via antigen presentation to the T cell receptor and signal two is provided by a co-receptor. In the absence of signal two, T cells remain unresponsive, thus these accessory proteins serve an essential purpose in an immune response. Co-receptors include two primary classes: co-stimulatory molecules and co-inhibitory molecules. Co-stimulatory molecules including CD80 and CD86, interact with CD28 to promote T cell proliferation and survival, while co-inhibitory molecules such as B7-DC, B7-H3 and B7-H4 limit the strength and duration of immune responses. In addition to orchestrating an immune response against pathogens, co-receptors have also been implicated in several diseases. Numerous studies have revealed abundant expression of inhibitory co-receptors in tumor microenvironments, contributing to tumor immunosuppression. Furthermore, lack of inhibitory signals in mouse models leads to lupus-like autoimmunity. While the rudimentary functions of these receptors are somewhat clear, the contexts in which they are expressed are incompletely understood. In this study, we aimed to fill this knowledge gap by investigating the effects of innate immune stimuli on expression of B7-family co-receptors. Our data demonstrate that stimulation of mouse splenocytes with synthetic Toll-like receptor agonists leads to selective alterations in co-receptor expression, most notably among B lymphocytes. These data suggest an avenue by which detection of conserved microbial motifs may modulate adaptive immunity through regulation of co-receptor expression on antigen presenting cells." @default.
- W4313355910 created "2023-01-06" @default.
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- W4313355910 date "2017-05-01" @default.
- W4313355910 modified "2023-10-12" @default.
- W4313355910 title "Stimulation through innate immune receptors selectively upregulates co-receptor expression on B cells" @default.
- W4313355910 doi "https://doi.org/10.4049/jimmunol.198.supp.152.18" @default.
- W4313355910 hasPublicationYear "2017" @default.
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