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- W4313355917 startingPage "153.13" @default.
- W4313355917 abstract "Abstract There is no licensed vaccine for protection against virulent strains of Francisella tularensis, an intracellular pathogen that replicates within lung macrophages and causes lethal acute infection in mice at an intranasal challenge dose of ~10 CFU. Immunization with the attenuated F. tularensis LVS strain provides some level of protection against virulent F. tularensis SchuS4 infection; however, the basis for this induced resistance remains unknown. We found that LVS vaccination allowed complete survival of BALB/c mice (but not C57Bl/6 mice) from lethal SchuS4 pulmonary challenge for 30 days, and 50% survival for at least 100 days, yet the surviving mice contained large numbers of SchuS4 organisms in their lungs and spleens (~104 CFU/organ). Early after challenge, resistant BALB/c mice produced greater amounts of Th17-associated cytokines compared to susceptible C57Bl/6 mice. However, IL-17 and IL-22 did not appear to be important for restricting chronic infection. On the other hand, depletion of either CD4+ or CD8+ cells three weeks after SchuS4 challenge caused resistant BALB/c mice to succumb to infection within one week. Similarly, treatment of vaccinated BALB/c mice with anti-IFNγ monoclonal antibodies three weeks after SchuS4 led to fatal acute tularemia. We conclude that LVS vaccination of BALB/c mice induces an immune response that allows the animals to constrain and tolerate a chronic SchuS4 infection. Long-term resistance is dependent on CD4+ cells, CD8+ cells, and IFNγ." @default.
- W4313355917 created "2023-01-06" @default.
- W4313355917 creator A5021196599 @default.
- W4313355917 creator A5057305767 @default.
- W4313355917 date "2017-05-01" @default.
- W4313355917 modified "2023-09-25" @default.
- W4313355917 title "LVS vaccination allows BALB/c mice to survive virulent <i>F. tularensis</i> pulmonary challenge but does not induce sterilizing immunity" @default.
- W4313355917 doi "https://doi.org/10.4049/jimmunol.198.supp.153.13" @default.
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