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- W4313355934 abstract "Abstract Objective Increasing research have focused on the potential therapeutic value of tolerogenic DC (tol-DC) in clinical organ transplantation. However, the role of long non-coding RNA (lncRNA) in tol-DC remains to be elucidated. Our report aims to illuminate the relationship between lncRNA NEAT1 and DC function in inmune tolerance of heart transplantation. Methods and Results We identified lncRNA NEAT1 was upregulated in cardiac allografts of mice by microarray. Applying Flow Cytometry, we found that LPS-dependent maturation of DC was inhibited after siNEAT1 characterizing the low expression of costimulatory molecular CD80, CD86 and MHCII. A mixed lymphocytere action (MLR) was performed to dectect the function of DC in simulating T cells. CD4+CD25+FoxP3+T cells were significantly increased in siNEAT1-DC, however, the proliferation of T cells was suppressed. Bioinformatic databases and dual-luciferase reporter gene assay confirmed that Neat1 can regulate mircoRNA let-7i. In addition, BALB/c recipients transfused with siNEAT1-DC had significantly prolonged allograft survival. Histological examination of cardiac allografts showd slight cell infiltration in recipients transfused with siNEAT1-DC. Conclusion LncRNA NEAT1 can regulate DC maturation and function, and transfusion of LPS-induced DC transfected with siNEAT1 prolonged allograft survival, besides, we identified that NEAT1 can regulate mircoRNA let-7i. This study enriched the network of interaction between lncRNA and mircoRNA and may provide a new therapeutic target in heart transplantation." @default.
- W4313355934 created "2023-01-06" @default.
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- W4313355934 date "2017-05-01" @default.
- W4313355934 modified "2023-10-11" @default.
- W4313355934 title "Silencing of lncRNA NEAT1 induces tolerogenic dendritic cells and immune tolerance in heart transplantation" @default.
- W4313355934 doi "https://doi.org/10.4049/jimmunol.198.supp.82.27" @default.
- W4313355934 hasPublicationYear "2017" @default.
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