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- W4313355935 abstract "Abstract The skin is home to a diverse and complex microbiota that play an important role in tissue homeostasis and local immunity. We have previously shown that Staphylococcus epidermidis promotes IL-17A-producing CD8+ T cells that enhance innate barrier immunity and limit pathogen invasion. However, the ability of other defined skin microbes and/or microbes-derived products to modulate skin immunity is still poorly characterized. T cells expressing low level of gamma delta TCR (gdT) are a dermal population of T lymphocytes that are committed to produce IL-17A and can mediate both innate and adaptive-like immune responses. Here, we show that cutaneous colonization with Corynebacterium accolens, a dominant member of the human and murine skin microbiota, induces IL-17A-producing gdT cells in the skin of specific-pathogen free mice. Intriguingly this ability is conserved amongst other species from the same genus supporting the idea that a canonical constituent shared by members of this taxon may be mediating this effect. Using a mutant strain of C. accolens lacking the corynemycolic acid synthase enzyme, we found that corynemycolic acids, a major component of the cell envelope, are important for the induction of IL-17A-producing gdT cells. Furthermore, mice associated with C. accolens displayed increased skin inflammation in an experimental model of psoriasis, a disease associated with an increase of IL-17A-producing gdT cells. Together these results uncover a novel mode of interaction between the skin microbiota and the skin immune system and highlight the important role that the skin microbiota may have in the pathogenesis of skin inflammatory disorders." @default.
- W4313355935 created "2023-01-06" @default.
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- W4313355935 date "2017-05-01" @default.
- W4313355935 modified "2023-09-28" @default.
- W4313355935 title "Specific interaction between defined skin commensal and dermal IL-17A-producing gamma delta T cells." @default.
- W4313355935 doi "https://doi.org/10.4049/jimmunol.198.supp.149.17" @default.
- W4313355935 hasPublicationYear "2017" @default.
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