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- W4313355945 abstract "Abstract Introduction Despite effective treatment HIV infection is characterized by non-AIDS health burdens, linked to immune activation, gut damage and microbial translocation. Some HIV+ individuals achieve viral suppression but do not recover blood CD4 T cells; these immunologic non-responders (INRs) are at elevated disease risk. We hypothesized that INRs have higher immune activation and markers related to gut damage, as compared to HIV+ treatment responders (TRs). Methods Thirty-six men who have sex with men (MSM) were recruited through the Maple Leaf Medical Clinic in Toronto. INRs (n=15) were defined as having a CD4 T cell count <350/μl, despite >2 years of HIV suppression. TRs (n=15) had a nadir CD4 T cell count <350/μl, but restored blood CD4 T cell count >350/μl. HIV-negative MSM (n=6) were also recruited. T cell activation (%HLA-DR+CD38+) and other cellular markers were assessed by flow cytometry. Plasma markers of coagulation (D-Dimer), and microbial translocation-associated immune activation (sCD14) were quantified by immunosorbent assay. Results INRs had elevated levels of CD8 and CD4 T cell activation compared to TRs (p<0.05). INRs had a reduced CD4/CD8 ratio compared to TRs (p<0.001), and lower CD4 T cell count was associated with elevated CD8 T cell activation (p<0.05). There was a trend towards higher plasma D-dimer levels in INRs compared to TRs (p=0.12). Conclusion INR men had a reduced CD4/CD8 ratio, higher levels of systemic immune activation, and a trending elevation in markers of coagulation. These data highlight a need for characterization of tissue-specific gut immune function in the INR context. Ultimately gut-targeted clinical interventions may be useful to mitigate adverse health outcomes in INR individuals." @default.
- W4313355945 created "2023-01-06" @default.
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- W4313355945 date "2017-05-01" @default.
- W4313355945 modified "2023-09-27" @default.
- W4313355945 title "Immunologic non-response during HIV infection is characterized by systemic immune activation" @default.
- W4313355945 doi "https://doi.org/10.4049/jimmunol.198.supp.125.3" @default.
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