Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313356030> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4313356030 endingPage "208.6" @default.
- W4313356030 startingPage "208.6" @default.
- W4313356030 abstract "Abstract Limitations in innate and adaptive immunity have been described early in life that contribute to susceptibility to microbial infection. Interleukin (IL)-27 is a heterodimeric cytokine produced primarily by antigen presenting cells and suppressive toward a variety of immune cell types. We have shown in humans and mice that neonatal macrophages express IL-27 at an elevated level as compared with adults. In mice this was shown to be maintained through infancy. Using the mouse as a model system, we have recently shown that myeloid-derived suppressor cells (MDSCs) are more abundant in the spleens of neonatal and infant mice and contribute to elevated IL-27 levels in young mice. Functional studies demonstrate that these MDSCs express active nitric oxide synthase, phagocytic oxidase complex, and arginase-1. Few studies have investigated the influence of MDSCs on innate immune function during bacterial infection. Streptococcus agalactiae and Escherichia coli are significant concerns for newborns as common causes of sepsis. We investigated the influence of neonatal and infant MDSCs cultured with infected macrophages and show impaired macrophage control of S. agalactiae and E. coli. Furthermore, the suppressive effect of MDSCs on macrophage function requires IL-27. Inclusion of a soluble receptor to neutralize IL-27 promotes increased control of bacterial growth. Our data suggests that the effect of MDSCs and IL-27 involves a direct influence on macrophage effector functions since inflammatory cytokines such as TNF and IL-6 are not significantly altered by the presence of MDSCs. Taken together these results suggest that the increased abundance of MDSCs and IL-27 production may contribute to some of the limitations in early life immunity." @default.
- W4313356030 created "2023-01-06" @default.
- W4313356030 creator A5017106160 @default.
- W4313356030 creator A5019044932 @default.
- W4313356030 creator A5025731640 @default.
- W4313356030 creator A5052204195 @default.
- W4313356030 creator A5074588752 @default.
- W4313356030 date "2017-05-01" @default.
- W4313356030 modified "2023-09-27" @default.
- W4313356030 title "Neonatal MDSCs compromise macrophage control of encapsulated bacteria" @default.
- W4313356030 doi "https://doi.org/10.4049/jimmunol.198.supp.208.6" @default.
- W4313356030 hasPublicationYear "2017" @default.
- W4313356030 type Work @default.
- W4313356030 citedByCount "0" @default.
- W4313356030 crossrefType "journal-article" @default.
- W4313356030 hasAuthorship W4313356030A5017106160 @default.
- W4313356030 hasAuthorship W4313356030A5019044932 @default.
- W4313356030 hasAuthorship W4313356030A5025731640 @default.
- W4313356030 hasAuthorship W4313356030A5052204195 @default.
- W4313356030 hasAuthorship W4313356030A5074588752 @default.
- W4313356030 hasConcept C121608353 @default.
- W4313356030 hasConcept C136449434 @default.
- W4313356030 hasConcept C164007495 @default.
- W4313356030 hasConcept C179185449 @default.
- W4313356030 hasConcept C193419808 @default.
- W4313356030 hasConcept C202751555 @default.
- W4313356030 hasConcept C203014093 @default.
- W4313356030 hasConcept C2775953899 @default.
- W4313356030 hasConcept C2777468819 @default.
- W4313356030 hasConcept C2777860557 @default.
- W4313356030 hasConcept C2778276568 @default.
- W4313356030 hasConcept C2778384902 @default.
- W4313356030 hasConcept C2778690821 @default.
- W4313356030 hasConcept C2779244956 @default.
- W4313356030 hasConcept C2779341262 @default.
- W4313356030 hasConcept C515207424 @default.
- W4313356030 hasConcept C523546767 @default.
- W4313356030 hasConcept C54355233 @default.
- W4313356030 hasConcept C55493867 @default.
- W4313356030 hasConcept C55721878 @default.
- W4313356030 hasConcept C86803240 @default.
- W4313356030 hasConcept C8891405 @default.
- W4313356030 hasConcept C89423630 @default.
- W4313356030 hasConceptScore W4313356030C121608353 @default.
- W4313356030 hasConceptScore W4313356030C136449434 @default.
- W4313356030 hasConceptScore W4313356030C164007495 @default.
- W4313356030 hasConceptScore W4313356030C179185449 @default.
- W4313356030 hasConceptScore W4313356030C193419808 @default.
- W4313356030 hasConceptScore W4313356030C202751555 @default.
- W4313356030 hasConceptScore W4313356030C203014093 @default.
- W4313356030 hasConceptScore W4313356030C2775953899 @default.
- W4313356030 hasConceptScore W4313356030C2777468819 @default.
- W4313356030 hasConceptScore W4313356030C2777860557 @default.
- W4313356030 hasConceptScore W4313356030C2778276568 @default.
- W4313356030 hasConceptScore W4313356030C2778384902 @default.
- W4313356030 hasConceptScore W4313356030C2778690821 @default.
- W4313356030 hasConceptScore W4313356030C2779244956 @default.
- W4313356030 hasConceptScore W4313356030C2779341262 @default.
- W4313356030 hasConceptScore W4313356030C515207424 @default.
- W4313356030 hasConceptScore W4313356030C523546767 @default.
- W4313356030 hasConceptScore W4313356030C54355233 @default.
- W4313356030 hasConceptScore W4313356030C55493867 @default.
- W4313356030 hasConceptScore W4313356030C55721878 @default.
- W4313356030 hasConceptScore W4313356030C86803240 @default.
- W4313356030 hasConceptScore W4313356030C8891405 @default.
- W4313356030 hasConceptScore W4313356030C89423630 @default.
- W4313356030 hasIssue "1_Supplement" @default.
- W4313356030 hasLocation W43133560301 @default.
- W4313356030 hasOpenAccess W4313356030 @default.
- W4313356030 hasPrimaryLocation W43133560301 @default.
- W4313356030 hasRelatedWork W1574628415 @default.
- W4313356030 hasRelatedWork W1975418102 @default.
- W4313356030 hasRelatedWork W2034779847 @default.
- W4313356030 hasRelatedWork W2103515427 @default.
- W4313356030 hasRelatedWork W2141330728 @default.
- W4313356030 hasRelatedWork W2188294308 @default.
- W4313356030 hasRelatedWork W2610389334 @default.
- W4313356030 hasRelatedWork W2986423947 @default.
- W4313356030 hasRelatedWork W3029450282 @default.
- W4313356030 hasRelatedWork W4313356030 @default.
- W4313356030 hasVolume "198" @default.
- W4313356030 isParatext "false" @default.
- W4313356030 isRetracted "false" @default.
- W4313356030 workType "article" @default.