Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313356076> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4313356076 endingPage "149.7" @default.
- W4313356076 startingPage "149.7" @default.
- W4313356076 abstract "Abstract Mucosal tissues including the gastrointestinal tract are important reservoirs for HIV replication. HIV-specific CD8 T cells are essential in controlling HIV infection. In order to gain insights into HIV-specific CD8 T cells in elite controllers (EC), we characterized this important cell population in rectal biopsies from EC using in situ tetramer staining combined with immunohistochemistry followed by quantitative analysis. Results showed tetramer+ HIV-specific CD8 T cells distributed unevenly throughout the rectal mucosa including within lymphoid aggregates. Frequencies of tetramer+ HIV-specific CD8 T cells ranged from 2 to 25 cells/mm2. A mean of 55% tetramer+ HIV-specific CD8 T cells expressed the effector protein perforin. Among the perforin+ HIV-specific T cells, the majority expressed low to medium levels of perforin and relatively few expressed high levels. In addition, we also observed a subset of perforin+ HIV-specific CD8 T cells in which perforin was located exclusively within the cell membrane, possibly representing a novel subset of armed resident or effector memory cells. Almost all tetramer+ HIV-specific CD8 T cells in the rectal mucosa were negative for Ki67, a marker for activation and proliferation (mean of 96%); many were PD-1+, a marker for recent T cell stimulation or exhaustion (mean of 59%), and some expressed CD103, a marker for a subset of resident memory T cells (mean of 6%). Taken together, these findings indicate that EC maintain diverse populations of memory HIV-specific CD8 T cells distributed throughout the rectal mucosa including within lymphoid aggregates and suggests that these cells are likely continually being exposed to antigen, but not dividing." @default.
- W4313356076 created "2023-01-06" @default.
- W4313356076 creator A5000166668 @default.
- W4313356076 creator A5000258038 @default.
- W4313356076 creator A5004843712 @default.
- W4313356076 creator A5034021476 @default.
- W4313356076 creator A5035322313 @default.
- W4313356076 creator A5059080499 @default.
- W4313356076 creator A5065731602 @default.
- W4313356076 creator A5069221243 @default.
- W4313356076 creator A5087945074 @default.
- W4313356076 date "2017-05-01" @default.
- W4313356076 modified "2023-09-27" @default.
- W4313356076 title "Distribution and phenotype of HIV-specific CD8 T cells <i>in situ</i> in the rectal mucosa of HIV+ elite controllers" @default.
- W4313356076 doi "https://doi.org/10.4049/jimmunol.198.supp.149.7" @default.
- W4313356076 hasPublicationYear "2017" @default.
- W4313356076 type Work @default.
- W4313356076 citedByCount "0" @default.
- W4313356076 crossrefType "journal-article" @default.
- W4313356076 hasAuthorship W4313356076A5000166668 @default.
- W4313356076 hasAuthorship W4313356076A5000258038 @default.
- W4313356076 hasAuthorship W4313356076A5004843712 @default.
- W4313356076 hasAuthorship W4313356076A5034021476 @default.
- W4313356076 hasAuthorship W4313356076A5035322313 @default.
- W4313356076 hasAuthorship W4313356076A5059080499 @default.
- W4313356076 hasAuthorship W4313356076A5065731602 @default.
- W4313356076 hasAuthorship W4313356076A5069221243 @default.
- W4313356076 hasAuthorship W4313356076A5087945074 @default.
- W4313356076 hasConcept C147483822 @default.
- W4313356076 hasConcept C153911025 @default.
- W4313356076 hasConcept C154317977 @default.
- W4313356076 hasConcept C167672396 @default.
- W4313356076 hasConcept C202751555 @default.
- W4313356076 hasConcept C203014093 @default.
- W4313356076 hasConcept C2776062744 @default.
- W4313356076 hasConcept C2776090121 @default.
- W4313356076 hasConcept C2777966294 @default.
- W4313356076 hasConcept C54355233 @default.
- W4313356076 hasConcept C86803240 @default.
- W4313356076 hasConcept C8891405 @default.
- W4313356076 hasConcept C95444343 @default.
- W4313356076 hasConceptScore W4313356076C147483822 @default.
- W4313356076 hasConceptScore W4313356076C153911025 @default.
- W4313356076 hasConceptScore W4313356076C154317977 @default.
- W4313356076 hasConceptScore W4313356076C167672396 @default.
- W4313356076 hasConceptScore W4313356076C202751555 @default.
- W4313356076 hasConceptScore W4313356076C203014093 @default.
- W4313356076 hasConceptScore W4313356076C2776062744 @default.
- W4313356076 hasConceptScore W4313356076C2776090121 @default.
- W4313356076 hasConceptScore W4313356076C2777966294 @default.
- W4313356076 hasConceptScore W4313356076C54355233 @default.
- W4313356076 hasConceptScore W4313356076C86803240 @default.
- W4313356076 hasConceptScore W4313356076C8891405 @default.
- W4313356076 hasConceptScore W4313356076C95444343 @default.
- W4313356076 hasIssue "1_Supplement" @default.
- W4313356076 hasLocation W43133560761 @default.
- W4313356076 hasOpenAccess W4313356076 @default.
- W4313356076 hasPrimaryLocation W43133560761 @default.
- W4313356076 hasRelatedWork W149686436 @default.
- W4313356076 hasRelatedWork W1601672058 @default.
- W4313356076 hasRelatedWork W1966777848 @default.
- W4313356076 hasRelatedWork W2017949628 @default.
- W4313356076 hasRelatedWork W2058581379 @default.
- W4313356076 hasRelatedWork W2552551254 @default.
- W4313356076 hasRelatedWork W2618779717 @default.
- W4313356076 hasRelatedWork W3016094068 @default.
- W4313356076 hasRelatedWork W3205830276 @default.
- W4313356076 hasRelatedWork W4200379672 @default.
- W4313356076 hasVolume "198" @default.
- W4313356076 isParatext "false" @default.
- W4313356076 isRetracted "false" @default.
- W4313356076 workType "article" @default.