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- W4313356099 abstract "Abstract Vasoactive intestinal peptide (VIP) is shown to have a role in the esophageal sphincter contraction and relaxation, and its role in pathogenesis of eosinophil associated allergic diseases like asthma and rhinitis is reported. Therefore, we tested the hypothesis that VIP may have an important role in the eosinophils accumulation in the esophagus that promote the pathogenesis of eosinophilic esophagitis (EoE). Accordingly, we performed flow cytometer analysis for VIP receptors expression in the blood eosinophils and real time PCR for VIP transcript analysis in the biopsies of human EoE. Herein, we show that human eosinophils highly express VIP associated receptor CRTH2, not VAPC1 or VAPC2. Further, VIP mRNA and protein is induced in esophageal biopsies of human EoE compare to the normal individuals. Additionally, we show that in vitro VIP has a similar chemoattractant activity for eosinophils as eotaxin. Further, we show that in vivo CRTH2 expressed eosinophils accumulated around the VIP producing nerves in the esophageal biopsies of EoE patients. Interestingly, we also observed VIP receptor VPAC2 on mast cells and their accumulation near the nerve cells in EoE biopsies. Taken together, we show the significance of VIP and its receptors interaction in the recruitment of eosinophils and mast cells that may have an important role in promoting chronic EoE pathogenesis in human." @default.
- W4313356099 created "2023-01-06" @default.
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- W4313356099 date "2017-05-01" @default.
- W4313356099 modified "2023-10-12" @default.
- W4313356099 title "Significance of VIP and VIP receptor interaction in promoting pathogenesis of Eosinophilic esophagitis" @default.
- W4313356099 doi "https://doi.org/10.4049/jimmunol.198.supp.194.18" @default.
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