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- W4313356109 abstract "Abstract Age-related macular degeneration (AMD) is a common disease causing blindness in the aging population. AMD affects central regions of the retina and choroid that can lose vision. This disease starts with drusen between retinal pigment epithelium(RPE) and Bruch’s membrane and finally results in neovascularization and destruction of retina. Hypoxic state is deeply associated with abnormal vessel formation in AMD. Hypoxia accumulate hypoxia-inducible factor-α(HIF-1α) and induce angiogenesis. In this study, we investigated that HIF-1α was upregulated in ARPE-19 cells which was exposed hypoxic states. Interestingly, celecoxib, an inhibitor of cyclooxygenase-2 (COX-2) could degrade HIF-1α on hypoxic RPE cells. We also observed that celecoxib blocked vascular endothelial growth factor (VEGF) production in hypoxic ARPE-19 cells, and conditioned media of celecoxib-treated ARPE-19 cells inhibited tube formations of HUVECs. We investigated that celecoxib might regulate degradation by ubiquitination/proteasome system, which were supported by MG-132, PYR-41 pretreatment experiments. Taken together, we suggest that these effects of celecoxib down-regulate angiogenesis through HIF-1α degradation and can support prevention of neovascularization of AMD." @default.
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- W4313356109 date "2017-05-01" @default.
- W4313356109 modified "2023-10-16" @default.
- W4313356109 title "Celecoxib down-regulates Angiogenic factor of Retinal Pigment Epithelial cells in Hypoxic state via HIF-1α degradation." @default.
- W4313356109 doi "https://doi.org/10.4049/jimmunol.198.supp.124.13" @default.
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