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- W4313356116 abstract "Abstract Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease. Glomerulonephritis is a major cause of morbidity in SLE. Glomerular proliferation is essential for the pathogenesis and progression of glomerular diseases. Nephrotoxic serum-mediated anti-glomerular basement membrane (anti-GBM) disease is a well-studied mouse model of immune-mediated glomerulonephritis. Axl receptor tyrosine kinase mediates glomerular cell survival signaling, resulting in proliferative responses. We previously showed that Axl-KO mice developed significantly reduced nephritis with improved kidney function and survival rate compared to the WT mice under the same treatment. In this study, we explore the therapeutic effect of Axl-specific small molecular inhibitor, R428, in anti-GBM nephritis. Our results show that R428 effectively prevents disease progression and exacerbation. Mesangial cell proliferation was greatly reduced in the R428-treatment mice. Mechanistic studies revealed that R428 suppresses the expression of pro-inflammatory cytokines and reduces Akt phosphorylation in the kidney. In summary, these results indicate that R428, currently under clinical trial in cancer patients, may have clinical therapeutic application in lupus nephritis patients." @default.
- W4313356116 created "2023-01-06" @default.
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- W4313356116 date "2017-05-01" @default.
- W4313356116 modified "2023-09-27" @default.
- W4313356116 title "R428 as a novel therapeutic agent for the treatment of experimental immune-mediated nephritis" @default.
- W4313356116 doi "https://doi.org/10.4049/jimmunol.198.supp.224.3" @default.
- W4313356116 hasPublicationYear "2017" @default.
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