Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313356145> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4313356145 endingPage "149.15" @default.
- W4313356145 startingPage "149.15" @default.
- W4313356145 abstract "Abstract The gastrointestinal tract (GIT) is an important site of HIV transmission and pathogenesis. Preventing or curing HIV infection will likely entail maintenance of protective anti-HIV immune responses in the GIT. Tissue resident memory T-cells (TRM) are long-lived, non-recirculating memory T-cells localized in tissues including the GIT. Positioned near sites of infection, TRM have protective efficacy against several pathogens. The precise role CD8+ TRM in HIV infection is not known. Blood and GIT CD8+ TRM cells from HIV+ and HIV- adults were identified by flow cytrometry using CD45RO, CD69, CD103, S1PR1, T-bet, and Eomesodermin (Eomes). Functionality was assessed in a 6-hour ex vivo stimulation assay. Cells were stimulated with DMSO, Gag, or Staphylococcal Enterotoxin B, and stained for CD107a, IFNγ, Mip-1β, TNFα, and IL-2. The frequency of CD103+CD69+S1PR1− CD8+ T-cells was significantly greater (P=0.005) in gut compared to blood (medians 54.8% and 0.10% respectively), indicative of tissue residency. CD45RO+ cells in this subset were classified as TRM. Consistent with murine studies, CD8+TRM were mainly T-betLowEomesNeg; however a population of EomesHigh CD8+ TRM emerged in HIV+ individuals not on antiretroviral therapy. Although polyfunctional Gag-specific CD8+ TRM responses (CD107a+, IFNγ+, Mip-1β+) appeared strongest in participants who control HIV without therapy (“controllers”), they constituted a smaller proportion of the total rectal Gag-specific CD8+ T-cell response compared to viremic participants not on ART (approximately 15% and 29% respectively). In summary, a large subset of CD8+ T-cells in rectal mucosa are TRM and likely play an important role in HIV-1 containment." @default.
- W4313356145 created "2023-01-06" @default.
- W4313356145 creator A5000258038 @default.
- W4313356145 creator A5004843712 @default.
- W4313356145 creator A5063704053 @default.
- W4313356145 creator A5065731602 @default.
- W4313356145 creator A5069221243 @default.
- W4313356145 creator A5085294184 @default.
- W4313356145 date "2017-05-01" @default.
- W4313356145 modified "2023-09-27" @default.
- W4313356145 title "Functionality of tissue-resident CD8+ T-cells in the human gastrointestinal tract during chronic HIV-1 infection." @default.
- W4313356145 doi "https://doi.org/10.4049/jimmunol.198.supp.149.15" @default.
- W4313356145 hasPublicationYear "2017" @default.
- W4313356145 type Work @default.
- W4313356145 citedByCount "0" @default.
- W4313356145 crossrefType "journal-article" @default.
- W4313356145 hasAuthorship W4313356145A5000258038 @default.
- W4313356145 hasAuthorship W4313356145A5004843712 @default.
- W4313356145 hasAuthorship W4313356145A5063704053 @default.
- W4313356145 hasAuthorship W4313356145A5065731602 @default.
- W4313356145 hasAuthorship W4313356145A5069221243 @default.
- W4313356145 hasAuthorship W4313356145A5085294184 @default.
- W4313356145 hasConcept C150903083 @default.
- W4313356145 hasConcept C154317977 @default.
- W4313356145 hasConcept C167672396 @default.
- W4313356145 hasConcept C202751555 @default.
- W4313356145 hasConcept C203014093 @default.
- W4313356145 hasConcept C207001950 @default.
- W4313356145 hasConcept C26291073 @default.
- W4313356145 hasConcept C2780512811 @default.
- W4313356145 hasConcept C2908647359 @default.
- W4313356145 hasConcept C55493867 @default.
- W4313356145 hasConcept C71924100 @default.
- W4313356145 hasConcept C86803240 @default.
- W4313356145 hasConcept C8891405 @default.
- W4313356145 hasConcept C99454951 @default.
- W4313356145 hasConceptScore W4313356145C150903083 @default.
- W4313356145 hasConceptScore W4313356145C154317977 @default.
- W4313356145 hasConceptScore W4313356145C167672396 @default.
- W4313356145 hasConceptScore W4313356145C202751555 @default.
- W4313356145 hasConceptScore W4313356145C203014093 @default.
- W4313356145 hasConceptScore W4313356145C207001950 @default.
- W4313356145 hasConceptScore W4313356145C26291073 @default.
- W4313356145 hasConceptScore W4313356145C2780512811 @default.
- W4313356145 hasConceptScore W4313356145C2908647359 @default.
- W4313356145 hasConceptScore W4313356145C55493867 @default.
- W4313356145 hasConceptScore W4313356145C71924100 @default.
- W4313356145 hasConceptScore W4313356145C86803240 @default.
- W4313356145 hasConceptScore W4313356145C8891405 @default.
- W4313356145 hasConceptScore W4313356145C99454951 @default.
- W4313356145 hasIssue "1_Supplement" @default.
- W4313356145 hasLocation W43133561451 @default.
- W4313356145 hasOpenAccess W4313356145 @default.
- W4313356145 hasPrimaryLocation W43133561451 @default.
- W4313356145 hasRelatedWork W1978694262 @default.
- W4313356145 hasRelatedWork W2018916009 @default.
- W4313356145 hasRelatedWork W2054101033 @default.
- W4313356145 hasRelatedWork W2327592239 @default.
- W4313356145 hasRelatedWork W2821255169 @default.
- W4313356145 hasRelatedWork W2981642747 @default.
- W4313356145 hasRelatedWork W4248950288 @default.
- W4313356145 hasRelatedWork W4251043635 @default.
- W4313356145 hasRelatedWork W4320081937 @default.
- W4313356145 hasRelatedWork W4320717881 @default.
- W4313356145 hasVolume "198" @default.
- W4313356145 isParatext "false" @default.
- W4313356145 isRetracted "false" @default.
- W4313356145 workType "article" @default.