Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313356444> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4313356444 endingPage "142.13" @default.
- W4313356444 startingPage "142.13" @default.
- W4313356444 abstract "Abstract Natural Killer T (NKT) cells are important in the initiation and regulation of immune responses to cancers. The observation that mantle cell lymphoma (MCL) patients have a significant reduction in both NKT cell number and function suggests that the antitumor effects mediated by these cells may be compromised. MCL is characterized by the chromosomal translocation and nuclear overexpression of Cyclin D1. Secondary chromosomal abnormalities and dysregulation of cell cycle machinery also contribute to MCL pathogenesis, such as aberrant or constitutive activation of phosphatidylinositol 3 kinase (PI3K). We hypothesize that constitutive activation of PI3K in MCL alters the repertoire of lipids in these cells, ultimately resulting in decreased CD1d-mediated NKT responses to MCL. In this study, we used small molecule pharmacologic inhibitors of PI3K (PI3Ki) to investigate the role of PI3K signaling on MCL survival and immunogenicity both in vitro and in vivo. Treatment with PI3Ki induced apoptosis in human MCL cell lines and enhanced their immunogenicity. In addition, we have found that treatment of peripheral blood mononuclear cells with isoform-specific PI3Ki does not suppress T cell activation; whereas, treatment with a pan PI3Ki, BEZ-235, completely abrogates NKT/T cell responses. These studies suggest inhibitors targeting individual isoforms may have higher therapeutic efficacy. Collectively, this work will advance our understanding of differences in the modes of PI3K signaling in MCL survival and in antigen processing and presentation." @default.
- W4313356444 created "2023-01-06" @default.
- W4313356444 creator A5008181619 @default.
- W4313356444 creator A5060580347 @default.
- W4313356444 date "2016-05-01" @default.
- W4313356444 modified "2023-09-23" @default.
- W4313356444 title "The role of PI3K in modulating NKT cell responses to Mantle Cell Lymphoma" @default.
- W4313356444 doi "https://doi.org/10.4049/jimmunol.196.supp.142.13" @default.
- W4313356444 hasPublicationYear "2016" @default.
- W4313356444 type Work @default.
- W4313356444 citedByCount "0" @default.
- W4313356444 crossrefType "journal-article" @default.
- W4313356444 hasAuthorship W4313356444A5008181619 @default.
- W4313356444 hasAuthorship W4313356444A5060580347 @default.
- W4313356444 hasConcept C139563560 @default.
- W4313356444 hasConcept C1491633281 @default.
- W4313356444 hasConcept C203014093 @default.
- W4313356444 hasConcept C2776090121 @default.
- W4313356444 hasConcept C2777525834 @default.
- W4313356444 hasConcept C2778607024 @default.
- W4313356444 hasConcept C2779338263 @default.
- W4313356444 hasConcept C502942594 @default.
- W4313356444 hasConcept C54355233 @default.
- W4313356444 hasConcept C62478195 @default.
- W4313356444 hasConcept C86554907 @default.
- W4313356444 hasConcept C86803240 @default.
- W4313356444 hasConcept C8891405 @default.
- W4313356444 hasConcept C95444343 @default.
- W4313356444 hasConceptScore W4313356444C139563560 @default.
- W4313356444 hasConceptScore W4313356444C1491633281 @default.
- W4313356444 hasConceptScore W4313356444C203014093 @default.
- W4313356444 hasConceptScore W4313356444C2776090121 @default.
- W4313356444 hasConceptScore W4313356444C2777525834 @default.
- W4313356444 hasConceptScore W4313356444C2778607024 @default.
- W4313356444 hasConceptScore W4313356444C2779338263 @default.
- W4313356444 hasConceptScore W4313356444C502942594 @default.
- W4313356444 hasConceptScore W4313356444C54355233 @default.
- W4313356444 hasConceptScore W4313356444C62478195 @default.
- W4313356444 hasConceptScore W4313356444C86554907 @default.
- W4313356444 hasConceptScore W4313356444C86803240 @default.
- W4313356444 hasConceptScore W4313356444C8891405 @default.
- W4313356444 hasConceptScore W4313356444C95444343 @default.
- W4313356444 hasIssue "1_Supplement" @default.
- W4313356444 hasLocation W43133564441 @default.
- W4313356444 hasOpenAccess W4313356444 @default.
- W4313356444 hasPrimaryLocation W43133564441 @default.
- W4313356444 hasRelatedWork W17784216 @default.
- W4313356444 hasRelatedWork W1965684523 @default.
- W4313356444 hasRelatedWork W2052793100 @default.
- W4313356444 hasRelatedWork W2070450011 @default.
- W4313356444 hasRelatedWork W2092599690 @default.
- W4313356444 hasRelatedWork W2095967285 @default.
- W4313356444 hasRelatedWork W2150316436 @default.
- W4313356444 hasRelatedWork W2554587248 @default.
- W4313356444 hasRelatedWork W2921443070 @default.
- W4313356444 hasRelatedWork W29274827 @default.
- W4313356444 hasVolume "196" @default.
- W4313356444 isParatext "false" @default.
- W4313356444 isRetracted "false" @default.
- W4313356444 workType "article" @default.