Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313356465> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4313356465 endingPage "211.2" @default.
- W4313356465 startingPage "211.2" @default.
- W4313356465 abstract "Abstract Regulatory T (Treg) cells, a distinct lineage of T cells, are required to maintain immunological tolerance. However, the molecular mechanism(s) by which Treg cells modulate tumor growth and clearance needs further investigation. Thus, the goal of this study is to analyze the absolute number and role of Treg cells during tumorigenesis. To achieve this goal, tumor induction studies were performed on C57/B6 mice using transgenic adenocarcinoma mouse prostate (TRAMP) cell lines C1, C2 and C3. Interestingly, TRAMP C1 and C2 are tumorigenic while TRAMP C3 fail to form tumor. C57/B6 mice treated with different tumorigenic concentrations of TRAMP (C1, C2, and C3) cells. The experimental design also included appropriate controls. Developing tumors, spleen and draining lymph nodes were dissected out and single cell suspensions were prepared. Cells were stained with the specific antibodies such as NK cells, NKT cells, CD4, CD8, macrophages, B cells and Treg cells and analyzed using a 13-color flowcytometer. Preliminary data revealed that development of tumors by TRAMP C1 and TRAMP C2 cells and non-tumorigenesis by TRAMP C3 cells was dependent on number of Treg cells in tumor microenvironment. Therefore, the data suggest that the number of Treg cells present in tumor microenvironment may have a direct impact on tumor progression and clearance. Thus, modulating the number of Treg cells in tumor microenvironment may be a successful therapeutic strategy to control tumor progression" @default.
- W4313356465 created "2023-01-06" @default.
- W4313356465 creator A5001424167 @default.
- W4313356465 creator A5010643028 @default.
- W4313356465 creator A5015911823 @default.
- W4313356465 creator A5017420879 @default.
- W4313356465 creator A5021839432 @default.
- W4313356465 creator A5038817160 @default.
- W4313356465 creator A5063272177 @default.
- W4313356465 date "2016-05-01" @default.
- W4313356465 modified "2023-09-23" @default.
- W4313356465 title "Regulatory T cells modulate tumor progression and clearance" @default.
- W4313356465 doi "https://doi.org/10.4049/jimmunol.196.supp.211.2" @default.
- W4313356465 hasPublicationYear "2016" @default.
- W4313356465 type Work @default.
- W4313356465 citedByCount "0" @default.
- W4313356465 crossrefType "journal-article" @default.
- W4313356465 hasAuthorship W4313356465A5001424167 @default.
- W4313356465 hasAuthorship W4313356465A5010643028 @default.
- W4313356465 hasAuthorship W4313356465A5015911823 @default.
- W4313356465 hasAuthorship W4313356465A5017420879 @default.
- W4313356465 hasAuthorship W4313356465A5021839432 @default.
- W4313356465 hasAuthorship W4313356465A5038817160 @default.
- W4313356465 hasAuthorship W4313356465A5063272177 @default.
- W4313356465 hasConcept C102230213 @default.
- W4313356465 hasConcept C104317684 @default.
- W4313356465 hasConcept C121608353 @default.
- W4313356465 hasConcept C141035611 @default.
- W4313356465 hasConcept C167672396 @default.
- W4313356465 hasConcept C203014093 @default.
- W4313356465 hasConcept C2776107976 @default.
- W4313356465 hasConcept C2779256057 @default.
- W4313356465 hasConcept C2780940892 @default.
- W4313356465 hasConcept C2781182431 @default.
- W4313356465 hasConcept C502942594 @default.
- W4313356465 hasConcept C54355233 @default.
- W4313356465 hasConcept C55493867 @default.
- W4313356465 hasConcept C555283112 @default.
- W4313356465 hasConcept C86803240 @default.
- W4313356465 hasConcept C8891405 @default.
- W4313356465 hasConceptScore W4313356465C102230213 @default.
- W4313356465 hasConceptScore W4313356465C104317684 @default.
- W4313356465 hasConceptScore W4313356465C121608353 @default.
- W4313356465 hasConceptScore W4313356465C141035611 @default.
- W4313356465 hasConceptScore W4313356465C167672396 @default.
- W4313356465 hasConceptScore W4313356465C203014093 @default.
- W4313356465 hasConceptScore W4313356465C2776107976 @default.
- W4313356465 hasConceptScore W4313356465C2779256057 @default.
- W4313356465 hasConceptScore W4313356465C2780940892 @default.
- W4313356465 hasConceptScore W4313356465C2781182431 @default.
- W4313356465 hasConceptScore W4313356465C502942594 @default.
- W4313356465 hasConceptScore W4313356465C54355233 @default.
- W4313356465 hasConceptScore W4313356465C55493867 @default.
- W4313356465 hasConceptScore W4313356465C555283112 @default.
- W4313356465 hasConceptScore W4313356465C86803240 @default.
- W4313356465 hasConceptScore W4313356465C8891405 @default.
- W4313356465 hasIssue "1_Supplement" @default.
- W4313356465 hasLocation W43133564651 @default.
- W4313356465 hasOpenAccess W4313356465 @default.
- W4313356465 hasPrimaryLocation W43133564651 @default.
- W4313356465 hasRelatedWork W2020076538 @default.
- W4313356465 hasRelatedWork W2121486217 @default.
- W4313356465 hasRelatedWork W2146774552 @default.
- W4313356465 hasRelatedWork W2165891408 @default.
- W4313356465 hasRelatedWork W2404235319 @default.
- W4313356465 hasRelatedWork W2773567891 @default.
- W4313356465 hasRelatedWork W2994995322 @default.
- W4313356465 hasRelatedWork W3158376733 @default.
- W4313356465 hasRelatedWork W3212842500 @default.
- W4313356465 hasRelatedWork W4214820210 @default.
- W4313356465 hasVolume "196" @default.
- W4313356465 isParatext "false" @default.
- W4313356465 isRetracted "false" @default.
- W4313356465 workType "article" @default.