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- W4313356564 abstract "Abstract The incidence of antibody-mediated kidney graft rejection has increased, but the key cellular and molecular participants underlying this graft injury remain unclear. We previously reported that kidney allograft rejection in CCR5−/− mice is dependent on donor-specific antibody (DSA). The current study determined if cells expressing cytotoxic function contributed to antibody-mediated kidney allograft rejection in CCR5−/− recipients. Wild type C57BL/6, B6.CCR5−/− and CD8−/−/CCR5−/− mice were transplanted with complete MHC mismatched A/J kidney grafts and intra-graft inflammatory components were followed to rejection. B6.CCR5−/− and CD8−/−/CCR5−/− recipients rejected the allografts by day 35 whereas 65% of allografts in wild type recipients survived past day 80 post-transplant. Allograft rejection in wild type recipients was associated with high titers of DSA, equivalent to those induced in CCR5-deficient recipients. Rejected allografts in C57BL/6, B6.CCR5−/− and CD8−/−/CCR5−/− recipients’ expressed high levels of VCAM-1 and MMP7 mRNA that was associated with high serum titers of DSA. At rejection in wild type and CD8−/−/CCR5−/− recipients, kidney allografts also expressed genes associated with NK cell (Sh2d1B1 and MYBL1) but not with T cell (CXCR6) activity during inflammation. High levels of perforin and granzyme B mRNA expression in kidney allografts peaked on day 6 post-transplant in all recipients. NK cell depletion in CD8−/−/CCR5−/− recipients reduced this expression to background levels and promoted long-term survival of 40% of kidney allografts. These results support a role for NK cells in increasing inflammation during antibody-mediated kidney allograft injury and rejection." @default.
- W4313356564 created "2023-01-06" @default.
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- W4313356564 date "2016-05-01" @default.
- W4313356564 modified "2023-09-29" @default.
- W4313356564 title "NK Cells Play a Critical Role in Mediating Inflammation and Graft Failure During Antibody-Mediated Rejection of Kidney Allografts" @default.
- W4313356564 doi "https://doi.org/10.4049/jimmunol.196.supp.140.17" @default.
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