Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313356608> ?p ?o ?g. }
Showing items 1 to 54 of
54
with 100 items per page.
- W4313356608 endingPage "52.13" @default.
- W4313356608 startingPage "52.13" @default.
- W4313356608 abstract "Abstract Myeloid cells – neutrophils, monocytes and dendritic cells (DCs) – play key roles in inflammation, immune defense against pathogens, and tissue repair and remodeling. Myelopoiesis, the production of myeloid cells by hematopoietic stem and progenitor cells, must be carefully regulated to support immune surveillance in the steady-state and meet the additional demands of emergency conditions such as infections. The current widely-accepted model of myelopoiesis describes the production of neutrophils by granulocyte-monocyte progenitors (GMPs), which also yield monocytes and DCs via monocyte-DC progenitors (MDPs). However, our data show that murine GMPs do not give rise to MDPs and that conventional and plasmacytoid DCs (cDCs and pDCs) are produced by MDPs but not GMPs. Thus GMPs and MDPs arise separately but both yield monocytes. Our in vitro and in vivo studies of the pathways and mechanisms of monocyte production have revealed that both GMPs and MDPs yield Ly6C+ inflammatory monocytes and Ly6C− CD43+ monocytes, but that GMP-derived and MDP-derived Ly6C+ inflammatory monocytes exhibit distinct patterns of gene expression. In ongoing studies we are comparing the phenotype and function of GMP- and MDP-derived monocytes, and determining the relative contributions of GMPs and MDPs to the monocyte and tissue macrophage pools under steady-state and emergency conditions." @default.
- W4313356608 created "2023-01-06" @default.
- W4313356608 creator A5027889843 @default.
- W4313356608 creator A5042050280 @default.
- W4313356608 date "2016-05-01" @default.
- W4313356608 modified "2023-09-28" @default.
- W4313356608 title "Independent production of distinct monocyte subsets by granulocyte-monocyte progenitors (GMPs) and monocyte-dendritic cell progenitors (MDPs)" @default.
- W4313356608 doi "https://doi.org/10.4049/jimmunol.196.supp.52.13" @default.
- W4313356608 hasPublicationYear "2016" @default.
- W4313356608 type Work @default.
- W4313356608 citedByCount "0" @default.
- W4313356608 crossrefType "journal-article" @default.
- W4313356608 hasAuthorship W4313356608A5027889843 @default.
- W4313356608 hasAuthorship W4313356608A5042050280 @default.
- W4313356608 hasConcept C109159458 @default.
- W4313356608 hasConcept C201750760 @default.
- W4313356608 hasConcept C203014093 @default.
- W4313356608 hasConcept C2779282312 @default.
- W4313356608 hasConcept C2781184567 @default.
- W4313356608 hasConcept C28328180 @default.
- W4313356608 hasConcept C86803240 @default.
- W4313356608 hasConcept C8891405 @default.
- W4313356608 hasConcept C95444343 @default.
- W4313356608 hasConcept C95862172 @default.
- W4313356608 hasConceptScore W4313356608C109159458 @default.
- W4313356608 hasConceptScore W4313356608C201750760 @default.
- W4313356608 hasConceptScore W4313356608C203014093 @default.
- W4313356608 hasConceptScore W4313356608C2779282312 @default.
- W4313356608 hasConceptScore W4313356608C2781184567 @default.
- W4313356608 hasConceptScore W4313356608C28328180 @default.
- W4313356608 hasConceptScore W4313356608C86803240 @default.
- W4313356608 hasConceptScore W4313356608C8891405 @default.
- W4313356608 hasConceptScore W4313356608C95444343 @default.
- W4313356608 hasConceptScore W4313356608C95862172 @default.
- W4313356608 hasIssue "1_Supplement" @default.
- W4313356608 hasLocation W43133566081 @default.
- W4313356608 hasOpenAccess W4313356608 @default.
- W4313356608 hasPrimaryLocation W43133566081 @default.
- W4313356608 hasRelatedWork W1957743255 @default.
- W4313356608 hasRelatedWork W1966630605 @default.
- W4313356608 hasRelatedWork W1967912020 @default.
- W4313356608 hasRelatedWork W1985119900 @default.
- W4313356608 hasRelatedWork W2066354959 @default.
- W4313356608 hasRelatedWork W2129879298 @default.
- W4313356608 hasRelatedWork W2136610354 @default.
- W4313356608 hasRelatedWork W2602767812 @default.
- W4313356608 hasRelatedWork W3136748876 @default.
- W4313356608 hasRelatedWork W4312039682 @default.
- W4313356608 hasVolume "196" @default.
- W4313356608 isParatext "false" @default.
- W4313356608 isRetracted "false" @default.
- W4313356608 workType "article" @default.