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- W4313356621 abstract "Abstract The majority of preclinical and clinical human immunodeficiency virus type 1 (HIV-1) vaccine development efforts have focused on HIV-1 subtype B strains from the western world. However, the overwhelming majority of HIV/AIDS-related deaths occur in the developing world and are from other HIV-1 subtype strains. Therefore, we sought to develop and generate the first mucosally transmissible simian-human immunodeficiency virus (SHIV) challenge stocks from HIV-1 subtype AE env sequences. The sequences were identified from acutely infected HIV-1 individuals from Southeast Asia. The challenge stocks efficiently infected rhesus monkeys, replicated to high levels during acute infection, and established chronic setpoint viremia. The SHIV challenge stocks should facilitate the evaluation of vaccines and other interventions aimed at controlling the spread of HIV-1 subtype AE infection." @default.
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- W4313356621 date "2015-05-01" @default.
- W4313356621 modified "2023-09-27" @default.
- W4313356621 title "Generation and evaluation of simian-human immunodeficiency virus subtype AE challenge stocks (VIR2P.1166)" @default.
- W4313356621 doi "https://doi.org/10.4049/jimmunol.194.supp.75.5" @default.
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