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- W4313356638 abstract "Abstract Dendritic Epithelial T Cells (DETCs) are generated exclusively in the fetal thymus and maintained in the skin epithelium throughout life. DETCs have limited antigenic specificity due to their exclusive usage of a canonical TCR. While the requirement of TCR in DETC development has been clearly demonstrated, the role of TCR in DETC function and lifelong maintenance is still poorly defined. To investigate the role of TCR signaling in DETCs, we used a γδ lineage specific and inducible Cre allele to delete the gene encoding Linker Activation in T cells (LAT), an essential signaling molecule downstream of the TCR. We found that LAT-mediated TCR signals in DETCs were required for proper activation of effector genes and optimal clonal expansion. The function of DETCs in wound healing was also dependent on LAT. Lack of proper TCR signaling prevented DETCs from efficient production of growth factors and cytokines involved in wound healing. Surprisingly, we found that long-term maintenance of DETCs in the skin was not affected by deletion of LAT. These findings demonstrate that LAT-mediated TCR signaling is required for optimal function and clonal expansion of DETCs and implies a LAT-independent mechanism for long-term survival and homeostatic turnover of DETCs in the skin epithelium." @default.
- W4313356638 created "2023-01-06" @default.
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- W4313356638 date "2015-05-01" @default.
- W4313356638 modified "2023-09-28" @default.
- W4313356638 title "LAT-mediated TCR signaling is required for optimal function and clonal expansion but not long-term survival and homeostatic turnover of DETCs (LYM7P.610)" @default.
- W4313356638 doi "https://doi.org/10.4049/jimmunol.194.supp.200.2" @default.
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