Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313356714> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4313356714 endingPage "49.2" @default.
- W4313356714 startingPage "49.2" @default.
- W4313356714 abstract "Abstract IL-17 is a pro-inflammatory cytokine that promotes autoimmunity and protects against certain pathogens. Here, we present a computational model of signaling downstream of the IL-17 receptor. To manage the complexity of the system we use a rule-based modeling approach, in which signaling proteins are modeled as structured objects and rules describe their biochemical interactions, allowing us to consider all possible complexes and phosphoforms generated from a set of basic molecules. This model encompasses major signaling components downstream of IL-17R, which activate NF-κB and in turn promote the production of pro-inflammatory cytokines. NF-κB also promotes production of A20, a deubiquitinating enzyme that inhibits NF-κB activation in multiple settings. We recently showed that A20 acts as a negative regulator of the IL-17 signaling pathway. By modeling A20 inhibition of TRAF6 and IKK, we are able to recapitulate experimentally-observed oscillations in NF-κB activity and A20 expression. Novel experimental data identifying the dynamics of signaling intermediates has further constrained model behavior and informed model development. Modeling the depletion of IκB, followed by its rebound above baseline levels, required the addition of a stochastic model of transcription factor binding, paired with a deterministic model of signaling events. We are currently using the hybrid model to identify which of several potential mechanisms A20 uses to attenuate IL-17 signaling." @default.
- W4313356714 created "2023-01-06" @default.
- W4313356714 creator A5020336186 @default.
- W4313356714 creator A5042442188 @default.
- W4313356714 creator A5049895849 @default.
- W4313356714 creator A5084213389 @default.
- W4313356714 date "2015-05-01" @default.
- W4313356714 modified "2023-10-01" @default.
- W4313356714 title "A computational model for mechanistic investigation of negative feedback in interleukin-17 receptor signaling (CCR3P.201)" @default.
- W4313356714 doi "https://doi.org/10.4049/jimmunol.194.supp.49.2" @default.
- W4313356714 hasPublicationYear "2015" @default.
- W4313356714 type Work @default.
- W4313356714 citedByCount "0" @default.
- W4313356714 crossrefType "journal-article" @default.
- W4313356714 hasAuthorship W4313356714A5020336186 @default.
- W4313356714 hasAuthorship W4313356714A5042442188 @default.
- W4313356714 hasAuthorship W4313356714A5049895849 @default.
- W4313356714 hasAuthorship W4313356714A5084213389 @default.
- W4313356714 hasConcept C104317684 @default.
- W4313356714 hasConcept C121332964 @default.
- W4313356714 hasConcept C150555746 @default.
- W4313356714 hasConcept C165801399 @default.
- W4313356714 hasConcept C170493617 @default.
- W4313356714 hasConcept C185592680 @default.
- W4313356714 hasConcept C203014093 @default.
- W4313356714 hasConcept C2778690821 @default.
- W4313356714 hasConcept C54355233 @default.
- W4313356714 hasConcept C62478195 @default.
- W4313356714 hasConcept C62520636 @default.
- W4313356714 hasConcept C6929976 @default.
- W4313356714 hasConcept C70721500 @default.
- W4313356714 hasConcept C86339819 @default.
- W4313356714 hasConcept C86803240 @default.
- W4313356714 hasConcept C93586867 @default.
- W4313356714 hasConcept C95444343 @default.
- W4313356714 hasConceptScore W4313356714C104317684 @default.
- W4313356714 hasConceptScore W4313356714C121332964 @default.
- W4313356714 hasConceptScore W4313356714C150555746 @default.
- W4313356714 hasConceptScore W4313356714C165801399 @default.
- W4313356714 hasConceptScore W4313356714C170493617 @default.
- W4313356714 hasConceptScore W4313356714C185592680 @default.
- W4313356714 hasConceptScore W4313356714C203014093 @default.
- W4313356714 hasConceptScore W4313356714C2778690821 @default.
- W4313356714 hasConceptScore W4313356714C54355233 @default.
- W4313356714 hasConceptScore W4313356714C62478195 @default.
- W4313356714 hasConceptScore W4313356714C62520636 @default.
- W4313356714 hasConceptScore W4313356714C6929976 @default.
- W4313356714 hasConceptScore W4313356714C70721500 @default.
- W4313356714 hasConceptScore W4313356714C86339819 @default.
- W4313356714 hasConceptScore W4313356714C86803240 @default.
- W4313356714 hasConceptScore W4313356714C93586867 @default.
- W4313356714 hasConceptScore W4313356714C95444343 @default.
- W4313356714 hasIssue "1_Supplement" @default.
- W4313356714 hasLocation W43133567141 @default.
- W4313356714 hasOpenAccess W4313356714 @default.
- W4313356714 hasPrimaryLocation W43133567141 @default.
- W4313356714 hasRelatedWork W1945713012 @default.
- W4313356714 hasRelatedWork W1970142567 @default.
- W4313356714 hasRelatedWork W2006210034 @default.
- W4313356714 hasRelatedWork W2108602815 @default.
- W4313356714 hasRelatedWork W2130108353 @default.
- W4313356714 hasRelatedWork W2158965995 @default.
- W4313356714 hasRelatedWork W2160471551 @default.
- W4313356714 hasRelatedWork W3091514528 @default.
- W4313356714 hasRelatedWork W3156027179 @default.
- W4313356714 hasRelatedWork W4323784234 @default.
- W4313356714 hasVolume "194" @default.
- W4313356714 isParatext "false" @default.
- W4313356714 isRetracted "false" @default.
- W4313356714 workType "article" @default.