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- W4313356716 startingPage "48.3" @default.
- W4313356716 abstract "Abstract Fibroblastic reticular cells (FRC) play an important role in maintaining immune homeostasis and orchestrating immune responses by producing chemokines and cytokines that promote immune cell migration, organization, function, and survival in secondary lymphoid organs. However, little is known about their function in the development and maintenance of inflammation in the tissue. Here we show that FRC-like cells can be found in inflamed islets of Langerhans in type 1 diabetes-prone NOD mice. No FRC are found in non-inflamed islets and crucially their number increases with severity of islet infiltration. Islet FRC share many characteristics of lymph node FRC, including CCL19 and IL-7 expression. However, in contrast to lymph node FRC, islet FRC are a major source of IFNγ-induced CXCL9 in inflamed islets, indicating their more proinflammatory phenotype. In addition, co-culture of islet FRC with activated T cells results in increased expression of proinflammatory molecules including granzymes, perforin, and IFNγ by T cells. Finally, LTβR-Ig treatment leads to dramatic reduction of islet FRC, which is associated with a significant loss of CD4 and CD8 T cells among islet infiltrates as early as 3 days after treatment. These data indicates FRC-like cells in inflamed tissue actively contribute to the local inflammatory responses and may act as a viable therapeutic target for the treatment of type 1 diabetes." @default.
- W4313356716 created "2023-01-06" @default.
- W4313356716 creator A5058743965 @default.
- W4313356716 creator A5065149701 @default.
- W4313356716 date "2015-05-01" @default.
- W4313356716 modified "2023-09-23" @default.
- W4313356716 title "Proinflammatory role of tissue-resident fibroblastic reticular cells (CAM1P.146)" @default.
- W4313356716 doi "https://doi.org/10.4049/jimmunol.194.supp.48.3" @default.
- W4313356716 hasPublicationYear "2015" @default.
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