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- W4313356720 abstract "Abstract Objective Sphingosine 1-phosphate receptor-3 (S1P3) is an important G protein-coupled receptor regulating host immune response. However, the role of S1P3 in polymicrobial sepsis remains unclear. Method Sepsis was induced in wild-type (WT) and S1PR3-deficient mice via cecal ligation and puncture (CLP). The mortality of mice, as well as organ injury and bacterial clearance during sepsis were assessed. The role of S1PR3 in sepsis was further confirmed by administration of an agonist peptide representing part of the intracellular domain of S1PR3 (GPS-725.017) in septic WT mice. Results S1PR3 deficient mice showed reduced survival rate, increased lung and liver damage, and more bacterial burden during sepsis. There was also significantly less macrophages chemotactic into the peritoneal cavity in the S1PR3 deficient mice. GPS-725.017 could active S1PR3, including internalization of the membrane protein S1PR3 into cytoplasm and activation of MAPKs signaling. In vivo, GPS-725.017 treatment increased recruitment of phagocyte into the peritoneal cavity, enhanced bacterial clearance and improved survival during sepsis. Conclusion The present findings uncover S1PR3 might be a critical modulator of macrophage chemotaxis in the pathogenesis of sepsis. The detailed mechanisms need to be further addressed." @default.
- W4313356720 created "2023-01-06" @default.
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- W4313356720 date "2015-05-01" @default.
- W4313356720 modified "2023-10-16" @default.
- W4313356720 title "Sphingosine 1-phosphate receptor-3 contributes to host defense against polymicrobial sepsis via modulating macrophage chemotaxis (CAM4P.161)" @default.
- W4313356720 doi "https://doi.org/10.4049/jimmunol.194.supp.185.19" @default.
- W4313356720 hasPublicationYear "2015" @default.
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