Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313356722> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4313356722 endingPage "72.16" @default.
- W4313356722 startingPage "72.16" @default.
- W4313356722 abstract "Abstract BACKGROUND: Recombinant adenovirus (Ad) vectors have recently garnered interest as vaccine platforms to elicit robust antibody (Ab) responses. In this study we seek to determine the timing of CD4 T cell help for the induction of these Ab responses. METHODS: B6 mice were immunized intramuscularly with 1010 vp of Ad serotype 26 expressing SIVmac239 Env. Anti-CD4 Ab (GK1.5) was used to deplete CD4 T cells. Serum Env-specific IgG was quantified by ELISA. Statistical analysis was performed by Mann-Whitney U test. RESULTS: Depletion of CD4 T cells at immunization completely abolished SIV Env-specific Ab responses at day 30 post-immunization. Surprisingly, by day 60 post-immunization Env-specific IgG responses spontaneously developed in these mice, and by day 90 these responses were of equal titer to those in control mice (Endpoint titer of 18225 for untreated vs. 12150 for anti-CD4 treated mice; P=0.9). Delayed Ab responses coincided temporally with the recovery of CD4 T cells following anti-CD4 Ab treatment. Recovery of CD4 T cells was necessary for this phenomenon, as repeated administration of anti-CD4 Ab blocked the development of Env-specific Ab responses long term. CONCLUSION: These data demonstrate that CD4 T cells actively promote the development of Ad vector-elicited Ab responses even when CD4 T cells are absent at the time of immunization. These data have potential implications for the utility of Ad vectors in immunocompromised individuals, such as AIDS patients." @default.
- W4313356722 created "2023-01-06" @default.
- W4313356722 creator A5000725987 @default.
- W4313356722 creator A5004102706 @default.
- W4313356722 creator A5017596711 @default.
- W4313356722 creator A5022314324 @default.
- W4313356722 creator A5026363921 @default.
- W4313356722 creator A5028748652 @default.
- W4313356722 creator A5032391866 @default.
- W4313356722 creator A5046451145 @default.
- W4313356722 creator A5054247332 @default.
- W4313356722 date "2015-05-01" @default.
- W4313356722 modified "2023-09-26" @default.
- W4313356722 title "Temporal regulation of adenovirus vector-elicited antibody responses by CD4 T cells (VAC4P.1111)" @default.
- W4313356722 doi "https://doi.org/10.4049/jimmunol.194.supp.72.16" @default.
- W4313356722 hasPublicationYear "2015" @default.
- W4313356722 type Work @default.
- W4313356722 citedByCount "0" @default.
- W4313356722 crossrefType "journal-article" @default.
- W4313356722 hasAuthorship W4313356722A5000725987 @default.
- W4313356722 hasAuthorship W4313356722A5004102706 @default.
- W4313356722 hasAuthorship W4313356722A5017596711 @default.
- W4313356722 hasAuthorship W4313356722A5022314324 @default.
- W4313356722 hasAuthorship W4313356722A5026363921 @default.
- W4313356722 hasAuthorship W4313356722A5028748652 @default.
- W4313356722 hasAuthorship W4313356722A5032391866 @default.
- W4313356722 hasAuthorship W4313356722A5046451145 @default.
- W4313356722 hasAuthorship W4313356722A5054247332 @default.
- W4313356722 hasConcept C104317684 @default.
- W4313356722 hasConcept C159047783 @default.
- W4313356722 hasConcept C159654299 @default.
- W4313356722 hasConcept C203014093 @default.
- W4313356722 hasConcept C22889606 @default.
- W4313356722 hasConcept C2776090121 @default.
- W4313356722 hasConcept C2780801004 @default.
- W4313356722 hasConcept C2993178667 @default.
- W4313356722 hasConcept C32470452 @default.
- W4313356722 hasConcept C32611913 @default.
- W4313356722 hasConcept C40767141 @default.
- W4313356722 hasConcept C54355233 @default.
- W4313356722 hasConcept C71924100 @default.
- W4313356722 hasConcept C86803240 @default.
- W4313356722 hasConcept C8891405 @default.
- W4313356722 hasConceptScore W4313356722C104317684 @default.
- W4313356722 hasConceptScore W4313356722C159047783 @default.
- W4313356722 hasConceptScore W4313356722C159654299 @default.
- W4313356722 hasConceptScore W4313356722C203014093 @default.
- W4313356722 hasConceptScore W4313356722C22889606 @default.
- W4313356722 hasConceptScore W4313356722C2776090121 @default.
- W4313356722 hasConceptScore W4313356722C2780801004 @default.
- W4313356722 hasConceptScore W4313356722C2993178667 @default.
- W4313356722 hasConceptScore W4313356722C32470452 @default.
- W4313356722 hasConceptScore W4313356722C32611913 @default.
- W4313356722 hasConceptScore W4313356722C40767141 @default.
- W4313356722 hasConceptScore W4313356722C54355233 @default.
- W4313356722 hasConceptScore W4313356722C71924100 @default.
- W4313356722 hasConceptScore W4313356722C86803240 @default.
- W4313356722 hasConceptScore W4313356722C8891405 @default.
- W4313356722 hasIssue "1_Supplement" @default.
- W4313356722 hasLocation W43133567221 @default.
- W4313356722 hasOpenAccess W4313356722 @default.
- W4313356722 hasPrimaryLocation W43133567221 @default.
- W4313356722 hasRelatedWork W1972745941 @default.
- W4313356722 hasRelatedWork W1984647379 @default.
- W4313356722 hasRelatedWork W2374934415 @default.
- W4313356722 hasRelatedWork W2375252691 @default.
- W4313356722 hasRelatedWork W2383557089 @default.
- W4313356722 hasRelatedWork W2384157809 @default.
- W4313356722 hasRelatedWork W2390062883 @default.
- W4313356722 hasRelatedWork W4307264905 @default.
- W4313356722 hasRelatedWork W4313356722 @default.
- W4313356722 hasRelatedWork W1840551154 @default.
- W4313356722 hasVolume "194" @default.
- W4313356722 isParatext "false" @default.
- W4313356722 isRetracted "false" @default.
- W4313356722 workType "article" @default.