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- W4313356735 abstract "Abstract Stimulation of cytotoxic lymphocytes via activating receptors results in aggregation of the receptors and recruitment of proximal signaling proteins at distinct location of the contact surface term signaling microclusters. The microclusters that are initially arise in the periphery of the contact surface then move centripetally to the center and signal when they are on the move. We examined the size and dynamics of CD16 activating signaling microclusters at the interface of CD16.NK-92 cells and supported lipid bilayers containing anti-CD16 antibody and ICAM-1, a ligand for integrin receptors, at different densities. We have found that variations in the ligation of integrins but not CD16 receptor significantly affect the microclusters’ size and their displacement and mobility. These and other data provided evidence that integrin signaling effectively modulate activating receptor proximal signaling and regulate the kinetics of cytolytic granule delivery and killing kinetics by cytotoxic lymphocytes." @default.
- W4313356735 created "2023-01-06" @default.
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- W4313356735 date "2015-05-01" @default.
- W4313356735 modified "2023-09-23" @default.
- W4313356735 title "Quantitation of activating signaling microclusters’ size and dynamics and their influence on killing kinetics by cytotoxic lymphocytes (TECH2P.915)" @default.
- W4313356735 doi "https://doi.org/10.4049/jimmunol.194.supp.206.25" @default.
- W4313356735 hasPublicationYear "2015" @default.
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