Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313356747> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4313356747 endingPage "187.2" @default.
- W4313356747 startingPage "187.2" @default.
- W4313356747 abstract "Abstract GWAS studies have identified polymorphisms in both IL33 and IL1RL1, the gene encoding ST2, the high affinity chain of the IL-33 receptor, that associate with asthma susceptibility. We identified amino acid changing variants in IL1RL1 associating with asthma incidence and found these SNPs to be protective from asthma risk in our study population. These variants result in coding changes to the intracellular region of ST2, which contains the TIR domain of the receptor that is critical for signaling downstream of IL-1 cytokine family and TLRs. Mutations or deletions to this region can inhibit ligand-induced responses. IL-33-mediated dimerization of ST2 and IL-1RAcP promotes TIR-TIR domain interaction and recruitment of the adaptor molecule MyD88 leading to AP-1 and NF-kB activation. IL-33 responses were diminished in cell lines expressing all 4 IL1RL1 missense variants. To further elucidate how this haplotype could affect IL-33 activity, we compared IL-33 activity and ST2 expression between donors carrying either haplotype. We observed reduced IL-33 mediated IL-8 secretion from purified blood eosinophils derived from individuals carrying the protective haplotype. We also observed greater soluble ST2 expression in these individuals. Our results provide a link between the genetic predisposition to asthma and IL-33 mediated responses. Given IL-33 promotes Th2 immunity, perturbations that diminish this response may provide protection from asthma risk." @default.
- W4313356747 created "2023-01-06" @default.
- W4313356747 creator A5024002311 @default.
- W4313356747 creator A5051487266 @default.
- W4313356747 creator A5055928722 @default.
- W4313356747 creator A5058236573 @default.
- W4313356747 creator A5068106006 @default.
- W4313356747 date "2015-05-01" @default.
- W4313356747 modified "2023-09-30" @default.
- W4313356747 title "Functional analysis of protective IL1RL1 variants associated with asthma risk (CCR6P.215)" @default.
- W4313356747 doi "https://doi.org/10.4049/jimmunol.194.supp.187.2" @default.
- W4313356747 hasPublicationYear "2015" @default.
- W4313356747 type Work @default.
- W4313356747 citedByCount "0" @default.
- W4313356747 crossrefType "journal-article" @default.
- W4313356747 hasAuthorship W4313356747A5024002311 @default.
- W4313356747 hasAuthorship W4313356747A5051487266 @default.
- W4313356747 hasAuthorship W4313356747A5055928722 @default.
- W4313356747 hasAuthorship W4313356747A5058236573 @default.
- W4313356747 hasAuthorship W4313356747A5068106006 @default.
- W4313356747 hasConcept C104317684 @default.
- W4313356747 hasConcept C135763542 @default.
- W4313356747 hasConcept C153209595 @default.
- W4313356747 hasConcept C170493617 @default.
- W4313356747 hasConcept C180754005 @default.
- W4313356747 hasConcept C197754878 @default.
- W4313356747 hasConcept C203014093 @default.
- W4313356747 hasConcept C501734568 @default.
- W4313356747 hasConcept C54355233 @default.
- W4313356747 hasConcept C75563809 @default.
- W4313356747 hasConcept C86803240 @default.
- W4313356747 hasConceptScore W4313356747C104317684 @default.
- W4313356747 hasConceptScore W4313356747C135763542 @default.
- W4313356747 hasConceptScore W4313356747C153209595 @default.
- W4313356747 hasConceptScore W4313356747C170493617 @default.
- W4313356747 hasConceptScore W4313356747C180754005 @default.
- W4313356747 hasConceptScore W4313356747C197754878 @default.
- W4313356747 hasConceptScore W4313356747C203014093 @default.
- W4313356747 hasConceptScore W4313356747C501734568 @default.
- W4313356747 hasConceptScore W4313356747C54355233 @default.
- W4313356747 hasConceptScore W4313356747C75563809 @default.
- W4313356747 hasConceptScore W4313356747C86803240 @default.
- W4313356747 hasIssue "1_Supplement" @default.
- W4313356747 hasLocation W43133567471 @default.
- W4313356747 hasOpenAccess W4313356747 @default.
- W4313356747 hasPrimaryLocation W43133567471 @default.
- W4313356747 hasRelatedWork W1782380426 @default.
- W4313356747 hasRelatedWork W1901150897 @default.
- W4313356747 hasRelatedWork W1966708416 @default.
- W4313356747 hasRelatedWork W1967429441 @default.
- W4313356747 hasRelatedWork W2064078062 @default.
- W4313356747 hasRelatedWork W2327017833 @default.
- W4313356747 hasRelatedWork W2377221997 @default.
- W4313356747 hasRelatedWork W2418740792 @default.
- W4313356747 hasRelatedWork W4250513280 @default.
- W4313356747 hasRelatedWork W860817473 @default.
- W4313356747 hasVolume "194" @default.
- W4313356747 isParatext "false" @default.
- W4313356747 isRetracted "false" @default.
- W4313356747 workType "article" @default.