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- W4313356768 abstract "Abstract Regulatory T (Treg) cells play an essential role in immune homeostasis. Under the pro-inflammatory settings such as autoimmune diseases, the function of Treg cells is impaired, in which pro-inflammatory cytokine IL-4 and IL-6 are involved in destabilizing Treg cells. However, the pathways that stabilize Treg cells have not been well understood. We have shown that cytokine-induced SH-2 protein (CIS) inhibits STAT3 and STAT6 activation; our current study indicates that CIS is required for stabilizing Treg cells in a Treg cell-intrinsic manner. Cis deficient Treg cells had impaired suppressive activity in vitro. Cis deficient mice on a T helper 2 (TH2) cells-prone background develop lymphadenopathy, splenomegaly and multiple organ inflammation, which is associated with spontaneous loss of Foxp3 expression and gain of TH2 cytokine expression in Treg cells. In addition to its role in cytoplasm, CIS also translocates into the nuclei in Treg cells which may serve as a second mechanism of surveillance for pro-inflammatory cytokine induced STAT6 (and maybe also STAT3) in the nuclei, and therefore contribute to stabilization of Treg cells." @default.
- W4313356768 created "2023-01-06" @default.
- W4313356768 creator A5021215353 @default.
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- W4313356768 date "2015-05-01" @default.
- W4313356768 modified "2023-09-28" @default.
- W4313356768 title "CIS inhibits effector programs in regulatory T cells (IRM15P.459)" @default.
- W4313356768 doi "https://doi.org/10.4049/jimmunol.194.supp.199.7" @default.
- W4313356768 hasPublicationYear "2015" @default.
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