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- W4313356811 endingPage "65.7" @default.
- W4313356811 startingPage "65.7" @default.
- W4313356811 abstract "Abstract A unique challenge for maternal immune cells during pregnancy is to tolerate an allogeneic fetus, and yet to remain competent to respond to invading pathogens. CD8+ effector T cells play a key role in protection against virus infections and may directly recognize fetal MHC alloantigens expressed on invading fetal extravillous trophoblasts (EVT). HLA-C is the only polymorphic MHC molecule expressed by EVT and a potential ligand for the TCR of decidual CD8+ T cells (CD8+ dT). The number of differentiated, effector-memory (EM) CD8+ dT at the fetal-maternal interface was increased at least two-fold, while naïve CD8+ dT were nearly absent. These EM CD8+ dT had reduced expression of the cytotoxic molecule perforin when compared to peripheral blood EM CD8+ T cells (CD8+ pT). However, upon stimulation with anti-CD3/28, CD8+ dT increased expression of perforin, granzyme B and secreted IFN-γ and TNFα. Thus, CD8+ dT are not anergic and are able to mount a cytolytic response. Furthermore, after co-culture with EVT for 3 days the degranulation potential of CD8+ dT and their secretion of TNFα were inhibited. Interestingly, degranulation was inhibited only when CD8+ dT and EVT were obtained from the same pregnancy, not when EVT and CD8+ dT came from unmatched samples. These data may suggest that EVT inhibit CD8+ dT in an antigen-specific manner. Antigen specificity of CD8+ dT and factors that prevent a cytolytic CD8+ dT response to allogeneic fetal EVT are key topics for future research." @default.
- W4313356811 created "2023-01-06" @default.
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- W4313356811 date "2015-05-01" @default.
- W4313356811 modified "2023-09-28" @default.
- W4313356811 title "Human decidual CD8+ effector T cell responses in pregnancy (MUC2P.924)" @default.
- W4313356811 doi "https://doi.org/10.4049/jimmunol.194.supp.65.7" @default.
- W4313356811 hasPublicationYear "2015" @default.
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