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- W4313356838 abstract "Abstract Alcohol and nicotine are both well known to cause depression of immune response; however, the effects of withdrawal from these substances have not been extensively explored. The impacts of exposure may arise from direct depression of the immune system or from the stress associated with exposure and withdrawal. In this study the immune response of adult male Rattus norvegicus was tested following exposure to both alcohol and nicotine, alcohol alone, nicotine alone, or neither (n=4/group). Nicotine or saline was administered 3 times per day for 10 days (0.3 mg/kg in saline; subcutaneous). Alcohol (25%w/v in nutritionally complete diet; intragastric) or isocaloric dextrose-containing diet was administered during days 7-10 of nicotine administration following the same thrice-daily schedule. Fecal samples were collected 4, 7, 11 and 14 days post exposure and fecal extractions were tested via ELISA to measure immunoglobulin A (IgA) levels. The effects of ethanol exposure, nicotine exposure, time post-exposure, and the interactions of the three were tested using a 3-way ANOVA. There was a significant decrease in IgA levels across groups on day 7 (p = 0.015), followed by an increase in IgA levels measured on day 10 in ethanol exposed groups (p = 0.011). This fluctuation in mucosal immunity following binge exposure to ethanol suggests that the impacts of even short term alcohol use impact the immune response during a withdrawal period." @default.
- W4313356838 created "2023-01-06" @default.
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- W4313356838 date "2015-05-01" @default.
- W4313356838 modified "2023-10-14" @default.
- W4313356838 title "Impacts of ethanol and nicotine withdrawal on fecal immunoglobulin A levels in rats (MUC3P.947)" @default.
- W4313356838 doi "https://doi.org/10.4049/jimmunol.194.supp.66.6" @default.
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