Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313357489> ?p ?o ?g. }
- W4313357489 endingPage "115403" @default.
- W4313357489 startingPage "115403" @default.
- W4313357489 abstract "Severe acne vulgaris is a common chronic inflammatory skin disease worldwide. 5-Aminolaevulinic acid photodynamic therapy (ALA-PDT) is effective and safe for severe acne. However, the mechanism is not fully understood. Intense acute inflammatory response at 24 h after ALA-PDT is reported positively correlated to the effectiveness. Inflammation regulation influence the progression or outcome of diseases. ALA-PDT may exert its therapeutic effect by augmenting intense inflammation and break the chronic inflammation. This study was set out to explore the mechanism of ALA-PDT augmenting intense acute inflammation in the treatment of acne. As a result, transcriptome microarrays analysis of severe acne patients showed that ALA-PDT significantly up-regulated expression of various inflammation-related genes, especially TREM1 and PTGS2, which were further confirmed by a C.acnes induced acne-like mouse ear model. The subsequent experiments demonstrated that ALA-PDT could trigger pro-inflammatory M1 polarization of macrophages in vitro and in vivo. Additionally, the crosstalk between keratinocytes and macrophages studied by a transwell co-culture system indicated that PGE2 secreted by ALA-PDT treated HaCaT cells could promote THP-1 macrophages M1 polarization by COX2/PGE2/TLR4/TREM1 axis to augment inflammation. Our study provides a novel insight that ALA-PDT could amplify inflammation by COX2/TREM1 mediated macrophages M1 polarization for the treatment of acne. It is hoped that this research will decipher the mechanism of ALA-PDT for the treatment of acne and provide a theoretical basis for optimizing the clinical ALA-PDT management." @default.
- W4313357489 created "2023-01-06" @default.
- W4313357489 creator A5005011787 @default.
- W4313357489 creator A5014393508 @default.
- W4313357489 creator A5018847810 @default.
- W4313357489 creator A5028909754 @default.
- W4313357489 creator A5036368125 @default.
- W4313357489 creator A5041438685 @default.
- W4313357489 creator A5048642002 @default.
- W4313357489 creator A5050056101 @default.
- W4313357489 creator A5075158998 @default.
- W4313357489 creator A5076690371 @default.
- W4313357489 creator A5088601096 @default.
- W4313357489 date "2023-02-01" @default.
- W4313357489 modified "2023-10-17" @default.
- W4313357489 title "ALA-PDT augments intense inflammation in the treatment of acne vulgaris by COX2/TREM1 mediated M1 macrophage polarization" @default.
- W4313357489 cites W1601476460 @default.
- W4313357489 cites W1620919780 @default.
- W4313357489 cites W1643888758 @default.
- W4313357489 cites W1929999284 @default.
- W4313357489 cites W1965037168 @default.
- W4313357489 cites W1969438318 @default.
- W4313357489 cites W1982923059 @default.
- W4313357489 cites W2036514375 @default.
- W4313357489 cites W2047747438 @default.
- W4313357489 cites W2060420887 @default.
- W4313357489 cites W2084889518 @default.
- W4313357489 cites W2103497341 @default.
- W4313357489 cites W2118550946 @default.
- W4313357489 cites W2123318646 @default.
- W4313357489 cites W2126219727 @default.
- W4313357489 cites W2129222816 @default.
- W4313357489 cites W2141768998 @default.
- W4313357489 cites W2149698238 @default.
- W4313357489 cites W2276726626 @default.
- W4313357489 cites W2591601356 @default.
- W4313357489 cites W2598186842 @default.
- W4313357489 cites W2599317326 @default.
- W4313357489 cites W2618886012 @default.
- W4313357489 cites W2732375683 @default.
- W4313357489 cites W2753114438 @default.
- W4313357489 cites W2791778287 @default.
- W4313357489 cites W2794366543 @default.
- W4313357489 cites W2810886224 @default.
- W4313357489 cites W2884081766 @default.
- W4313357489 cites W2947191936 @default.
- W4313357489 cites W2953564389 @default.
- W4313357489 cites W2974291499 @default.
- W4313357489 cites W3031700699 @default.
- W4313357489 cites W3048196286 @default.
- W4313357489 cites W3083343427 @default.
- W4313357489 cites W3088818802 @default.
- W4313357489 cites W3118600436 @default.
- W4313357489 cites W3156253409 @default.
- W4313357489 cites W3203362935 @default.
- W4313357489 cites W3210034102 @default.
- W4313357489 cites W3214810036 @default.
- W4313357489 cites W4210766290 @default.
- W4313357489 cites W4211104405 @default.
- W4313357489 cites W4226218251 @default.
- W4313357489 cites W86026435 @default.
- W4313357489 doi "https://doi.org/10.1016/j.bcp.2022.115403" @default.
- W4313357489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36592708" @default.
- W4313357489 hasPublicationYear "2023" @default.
- W4313357489 type Work @default.
- W4313357489 citedByCount "4" @default.
- W4313357489 countsByYear W43133574892023 @default.
- W4313357489 crossrefType "journal-article" @default.
- W4313357489 hasAuthorship W4313357489A5005011787 @default.
- W4313357489 hasAuthorship W4313357489A5014393508 @default.
- W4313357489 hasAuthorship W4313357489A5018847810 @default.
- W4313357489 hasAuthorship W4313357489A5028909754 @default.
- W4313357489 hasAuthorship W4313357489A5036368125 @default.
- W4313357489 hasAuthorship W4313357489A5041438685 @default.
- W4313357489 hasAuthorship W4313357489A5048642002 @default.
- W4313357489 hasAuthorship W4313357489A5050056101 @default.
- W4313357489 hasAuthorship W4313357489A5075158998 @default.
- W4313357489 hasAuthorship W4313357489A5076690371 @default.
- W4313357489 hasAuthorship W4313357489A5088601096 @default.
- W4313357489 hasConcept C16005928 @default.
- W4313357489 hasConcept C178790620 @default.
- W4313357489 hasConcept C185592680 @default.
- W4313357489 hasConcept C202751555 @default.
- W4313357489 hasConcept C203014093 @default.
- W4313357489 hasConcept C2776682551 @default.
- W4313357489 hasConcept C2776914184 @default.
- W4313357489 hasConcept C2777673923 @default.
- W4313357489 hasConcept C2779244956 @default.
- W4313357489 hasConcept C2779900937 @default.
- W4313357489 hasConcept C2781323092 @default.
- W4313357489 hasConcept C502942594 @default.
- W4313357489 hasConcept C55493867 @default.
- W4313357489 hasConcept C71924100 @default.
- W4313357489 hasConcept C86803240 @default.
- W4313357489 hasConceptScore W4313357489C16005928 @default.
- W4313357489 hasConceptScore W4313357489C178790620 @default.
- W4313357489 hasConceptScore W4313357489C185592680 @default.
- W4313357489 hasConceptScore W4313357489C202751555 @default.