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- W4313358904 abstract "Abstract Rare individuals, termed HIV controllers, spontaneously control HIV infection by mounting efficient T cell responses against the virus. Protective CD4+ T cell responses from HIV controllers involve high affinity public T cell receptors (TCRs) recognizing an immunodominant capsid epitope (Gag293) presented by a remarkably broad array of HLA class II molecules. Here we determine the structures of a prototypical public TCR bound to HLAD-R1, –DR11, and –DR15 molecules presenting the Gag293 epitope. TCR recognition was driven by contacts with the Gag293 epitope, a feature that underpinned the extensive HLA cross-restriction. These high affinity TCRs promoted mature immunological synapse formation and cytotoxic capacity in both CD4+ and CD8+ T cells. The public TCRs suppressed HIV replication in multiple genetic backgrounds ex vivo, emphasizing the functional advantage conferred by broad HLA class II cross-restriction." @default.
- W4313358904 created "2023-01-06" @default.
- W4313358904 creator A5088068626 @default.
- W4313358904 date "2020-05-01" @default.
- W4313358904 modified "2023-09-26" @default.
- W4313358904 title "CD4+ T cell mediated HLA class II cross-restriction in HIV controllers" @default.
- W4313358904 doi "https://doi.org/10.4049/jimmunol.204.supp.217.9" @default.
- W4313358904 hasPublicationYear "2020" @default.
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