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- W4313358954 abstract "Abstract Granzymes have been implicated in numerous diseases including arthritis, viral and bacterial infections, hypersensitivity, autoimmune diabetes, and some cancers. In a STAT6 transgenic mouse model of atopic dermatitis, we identified a population of Granzyme A expressing CD4-T- cells. The role that these cells play in disease is unclear. To define their phenotype, we generated granzyme A (GrA)-expressing T helper cells in vitro using a combination of IL-4/IL-6 and IL-21. GrA-expressing TH cells did not express other TH subsetassociated cytokines, and other TH subsets did not appreciably express GrA. To further examine the development and function of GrA+ TH cells, we developed a Granzyme A-GFP reporter allele termed Grama (GrA Monitoring Allele) mouse. Grama+ cells were identified in the spleen and intestine. Using RNA-seq analysis of in vitro derived cells, we additionally identified several genes, including Arg1, Zpbp2, and Rpl39, that were enriched in GrA-expressing T cells. Thus, GrA-expressing CD4 T cells may represent a novel TH subset and it will be interesting to define the function of this subset in inflammatory diseases." @default.
- W4313358954 created "2023-01-06" @default.
- W4313358954 creator A5026136896 @default.
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- W4313358954 date "2019-05-01" @default.
- W4313358954 modified "2023-09-26" @default.
- W4313358954 title "Defining the Phenotype and Function of Granzyme A Expressing T-Helper Cells" @default.
- W4313358954 doi "https://doi.org/10.4049/jimmunol.202.supp.181.2" @default.
- W4313358954 hasPublicationYear "2019" @default.
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