Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313358977> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4313358977 endingPage "56.12" @default.
- W4313358977 startingPage "56.12" @default.
- W4313358977 abstract "Abstract Opioids are heavily prescribed medications used to treat chronic pain. Since their additional response includes euphoria, there is an exceedingly high addiction rate that has led to a country wide epidemic of opioid misuse. Opioid effects are not limited to the nervous system, since leukocytes express opioid receptors, which are G-protein coupled receptors known as μ, δ, and κ, suggesting that natural and synthetic opioids might regulate the immune system. Based on previously published reports, we hypothesized that opioids induce distinct regulatory pathways in CD4+ T cells that results in inhibition of the immune response. CD4+ T cells are isolated by negative selection from peripheral blood mononuclear cell and opioid receptor expression is assessed on resting and activated T cells using flow cytometry. Two models of opioid exposure in vitro were developed to study the effects of opioids on CD4+ T cell activation. Cells were treated with a δ opioid receptor specific agonist (DPDPE) for 24 h before or after activation and harvested 24 h after the second treatment and stained for expression of a well characterized early T cell activation marker – CD69. Cells treated with an opioid after activation showed no major shifts in CD69 intensity, suggesting opioids had no influence on a previously activated T cell. However, CD4+ T cells treated with an opioid before activation exhibited an increase in CD69 expression, suggesting an unexpected enhancement of T cell activation. In conclusion, opioids seem to play distinct biological activities depending on the activation state of the CD4+ T cell, and may function as both immunoinhibitory and immunostimulatory agents. Future studies will identify the mechanisms by which opioids regulate immunity." @default.
- W4313358977 created "2023-01-06" @default.
- W4313358977 creator A5000107954 @default.
- W4313358977 creator A5057616503 @default.
- W4313358977 date "2019-05-01" @default.
- W4313358977 modified "2023-09-27" @default.
- W4313358977 title "Immune modulation caused by synthetic opioids during CD4+ T cell activation" @default.
- W4313358977 doi "https://doi.org/10.4049/jimmunol.202.supp.56.12" @default.
- W4313358977 hasPublicationYear "2019" @default.
- W4313358977 type Work @default.
- W4313358977 citedByCount "0" @default.
- W4313358977 crossrefType "journal-article" @default.
- W4313358977 hasAuthorship W4313358977A5000107954 @default.
- W4313358977 hasAuthorship W4313358977A5057616503 @default.
- W4313358977 hasConcept C126322002 @default.
- W4313358977 hasConcept C137061746 @default.
- W4313358977 hasConcept C14397066 @default.
- W4313358977 hasConcept C170493617 @default.
- W4313358977 hasConcept C185592680 @default.
- W4313358977 hasConcept C202751555 @default.
- W4313358977 hasConcept C203014093 @default.
- W4313358977 hasConcept C2776090121 @default.
- W4313358977 hasConcept C2776401185 @default.
- W4313358977 hasConcept C2778938600 @default.
- W4313358977 hasConcept C2779886867 @default.
- W4313358977 hasConcept C2781063702 @default.
- W4313358977 hasConcept C553184892 @default.
- W4313358977 hasConcept C55493867 @default.
- W4313358977 hasConcept C71924100 @default.
- W4313358977 hasConcept C86803240 @default.
- W4313358977 hasConcept C88016717 @default.
- W4313358977 hasConcept C8891405 @default.
- W4313358977 hasConcept C95444343 @default.
- W4313358977 hasConcept C98274493 @default.
- W4313358977 hasConceptScore W4313358977C126322002 @default.
- W4313358977 hasConceptScore W4313358977C137061746 @default.
- W4313358977 hasConceptScore W4313358977C14397066 @default.
- W4313358977 hasConceptScore W4313358977C170493617 @default.
- W4313358977 hasConceptScore W4313358977C185592680 @default.
- W4313358977 hasConceptScore W4313358977C202751555 @default.
- W4313358977 hasConceptScore W4313358977C203014093 @default.
- W4313358977 hasConceptScore W4313358977C2776090121 @default.
- W4313358977 hasConceptScore W4313358977C2776401185 @default.
- W4313358977 hasConceptScore W4313358977C2778938600 @default.
- W4313358977 hasConceptScore W4313358977C2779886867 @default.
- W4313358977 hasConceptScore W4313358977C2781063702 @default.
- W4313358977 hasConceptScore W4313358977C553184892 @default.
- W4313358977 hasConceptScore W4313358977C55493867 @default.
- W4313358977 hasConceptScore W4313358977C71924100 @default.
- W4313358977 hasConceptScore W4313358977C86803240 @default.
- W4313358977 hasConceptScore W4313358977C88016717 @default.
- W4313358977 hasConceptScore W4313358977C8891405 @default.
- W4313358977 hasConceptScore W4313358977C95444343 @default.
- W4313358977 hasConceptScore W4313358977C98274493 @default.
- W4313358977 hasIssue "1_Supplement" @default.
- W4313358977 hasLocation W43133589771 @default.
- W4313358977 hasOpenAccess W4313358977 @default.
- W4313358977 hasPrimaryLocation W43133589771 @default.
- W4313358977 hasRelatedWork W1966153991 @default.
- W4313358977 hasRelatedWork W197448374 @default.
- W4313358977 hasRelatedWork W1976394800 @default.
- W4313358977 hasRelatedWork W1982495583 @default.
- W4313358977 hasRelatedWork W2002381450 @default.
- W4313358977 hasRelatedWork W2002907041 @default.
- W4313358977 hasRelatedWork W2032408015 @default.
- W4313358977 hasRelatedWork W2046839501 @default.
- W4313358977 hasRelatedWork W2074264681 @default.
- W4313358977 hasRelatedWork W2091330110 @default.
- W4313358977 hasVolume "202" @default.
- W4313358977 isParatext "false" @default.
- W4313358977 isRetracted "false" @default.
- W4313358977 workType "article" @default.