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- W4313359043 abstract "Abstract Many strategies are being investigated to induce and sustain anti-tumor immune responses through vaccination. Viral vectors have been used to induce robust cellular immune responses, however due to immune responses against the vector they loose potency with boosting vaccinations. In this study, we investigated a heterologous prime boost strategy that combines lentivirus and peptide vaccination to induce robust anti-tumour immune responses in a preclinical model. DepoVax™ is a water-free vaccine formulation that facilities strong and sustained immune responses to peptide antigens. We showed that while homologous immunizations with DepoVax peptide vaccine containing HPV16 E749–57 T cell peptide antigen (DPX-FP) elicit potent antigen-specific responses, heterologous prime-boost immunizations with DPX-FP and lentivector vaccine expressing HPV16 E7 protein could further enhance systemic immune responses detected by IFN-γ ELISPOT. The synergy between two vaccines is influenced by the order of vaccine administration, dose, and delivery route. Using an HPV-expressing murine tumor model (C3), we found that heterologous priming with the DPX-FP vaccine and boosting with E7 lentivector vaccine enhanced tumor control and increased survival rates as compared to the treatments with either vaccine alone. RT-qPCR profiling demonstrated that the vaccine-draining lymph node cells of mice primed with DPX-FP and boosted with E7 lentivector vaccine had an altered immune gene signature with an increased expression of cytotoxic T lymphocyte markers (Gzmb and Tbx21). Taken together our results support a rationale for combining DepoVax based therapy with lentivector vaccines in future clinical trials." @default.
- W4313359043 created "2023-01-06" @default.
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- W4313359043 date "2018-05-01" @default.
- W4313359043 modified "2023-09-23" @default.
- W4313359043 title "Combination of a DepoVax™ peptide vaccine with a lentivector vaccine induces strong antigen-specific immune responses and provides effective tumor control in murine models" @default.
- W4313359043 doi "https://doi.org/10.4049/jimmunol.200.supp.181.3" @default.
- W4313359043 hasPublicationYear "2018" @default.
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