Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313359058> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4313359058 endingPage "115.21" @default.
- W4313359058 startingPage "115.21" @default.
- W4313359058 abstract "Abstract T regulatory cells (Treg) play a significant role in maintaining self-tolerance and preventing autoimmune diseases. We and others have shown that low dose favors Treg and T helper (Th) 2 cell differentiation, while high Ag dose stimulation activates the PI3K/Akt/mTOR pathway, favoring inflammatory Th1 and Th17 cell differentiation (Tconv). Differences in PI3K/Akt/mTOR signaling not only affects T cell fate but our research shows that Akt phosphorylation of the RNA-binding protein, (RBP) heterogeneous nuclear ribonucleoprotein (hnRNP) A1, is dependent on TCR signal strength. RBPs such as hnRNPA1 are emerging as regulators of RNA processing and stability in immune cells, and the effect of RBP on T cell differentiation is a growing subject of interest. We have shown hnRNPA1 is required for optimal Treg differentiation by performing knockdown experiments, and our present research is focused on identifying a role for Akt phosphorylation in hnRNPA1 function. HnRNPA1 is known to have a single Akt phosphorylation site at S199 and our lab has generated a new mutant mouse model, hnRNPA1-S199A (mA1). This mutation affects the ability of Akt to phosphorylate hnRNPA1 in all immune cells. Using Cytek’s Aurora flow cytometer we characterized the immune cell populations of mA1 at steady state. Preliminary data do not indicate any major changes in innate immune and B cells populations at steady state. We observed modest changes in CD4 T cell population frequencies at steady state. Current work using In vitro skewing suggests that Akt phosphorylation of hnRNPA1 influences Treg fate. This project suggests a novel mechanism by which Akt modulates T cell fate." @default.
- W4313359058 created "2023-01-06" @default.
- W4313359058 creator A5025762930 @default.
- W4313359058 creator A5053688020 @default.
- W4313359058 creator A5069253674 @default.
- W4313359058 creator A5070385508 @default.
- W4313359058 date "2019-05-01" @default.
- W4313359058 modified "2023-09-23" @default.
- W4313359058 title "Understanding how AKT phosphorylation of hnRNPA1 modulates T cell fate and function" @default.
- W4313359058 doi "https://doi.org/10.4049/jimmunol.202.supp.115.21" @default.
- W4313359058 hasPublicationYear "2019" @default.
- W4313359058 type Work @default.
- W4313359058 citedByCount "0" @default.
- W4313359058 crossrefType "journal-article" @default.
- W4313359058 hasAuthorship W4313359058A5025762930 @default.
- W4313359058 hasAuthorship W4313359058A5053688020 @default.
- W4313359058 hasAuthorship W4313359058A5069253674 @default.
- W4313359058 hasAuthorship W4313359058A5070385508 @default.
- W4313359058 hasConcept C11960822 @default.
- W4313359058 hasConcept C203014093 @default.
- W4313359058 hasConcept C2908647359 @default.
- W4313359058 hasConcept C62478195 @default.
- W4313359058 hasConcept C71924100 @default.
- W4313359058 hasConcept C75217442 @default.
- W4313359058 hasConcept C86554907 @default.
- W4313359058 hasConcept C86803240 @default.
- W4313359058 hasConcept C8891405 @default.
- W4313359058 hasConcept C95444343 @default.
- W4313359058 hasConcept C99454951 @default.
- W4313359058 hasConceptScore W4313359058C11960822 @default.
- W4313359058 hasConceptScore W4313359058C203014093 @default.
- W4313359058 hasConceptScore W4313359058C2908647359 @default.
- W4313359058 hasConceptScore W4313359058C62478195 @default.
- W4313359058 hasConceptScore W4313359058C71924100 @default.
- W4313359058 hasConceptScore W4313359058C75217442 @default.
- W4313359058 hasConceptScore W4313359058C86554907 @default.
- W4313359058 hasConceptScore W4313359058C86803240 @default.
- W4313359058 hasConceptScore W4313359058C8891405 @default.
- W4313359058 hasConceptScore W4313359058C95444343 @default.
- W4313359058 hasConceptScore W4313359058C99454951 @default.
- W4313359058 hasIssue "1_Supplement" @default.
- W4313359058 hasLocation W43133590581 @default.
- W4313359058 hasOpenAccess W4313359058 @default.
- W4313359058 hasPrimaryLocation W43133590581 @default.
- W4313359058 hasRelatedWork W1970121416 @default.
- W4313359058 hasRelatedWork W2026199302 @default.
- W4313359058 hasRelatedWork W2037154041 @default.
- W4313359058 hasRelatedWork W2038169799 @default.
- W4313359058 hasRelatedWork W2045005486 @default.
- W4313359058 hasRelatedWork W2135050229 @default.
- W4313359058 hasRelatedWork W2168778208 @default.
- W4313359058 hasRelatedWork W2170704593 @default.
- W4313359058 hasRelatedWork W2376211306 @default.
- W4313359058 hasRelatedWork W2744183625 @default.
- W4313359058 hasVolume "202" @default.
- W4313359058 isParatext "false" @default.
- W4313359058 isRetracted "false" @default.
- W4313359058 workType "article" @default.