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- W4313359061 abstract "Abstract Type 1 Diabetes (T1D) is caused by T cell-mediated destruction of pancreatic beta cells. The “fertile field” hypothesis of T1D proposes that, in a genetically predisposed individual, an inflamed environment prompts the organ towards autoimmunity. In this context, the protective role of the cytokine IL-10 remains unclear and somewhat controversial. Here we tested whether chronic and localized accumulation of type-I interferons (TI-IFNs) creates a “fertile field” that releases diabetogenic T cells from IL-10 mediated regulation and prompts T1D development. In vitro incubation of mouse T cells with IFN-b induces a dramatic defect in the production of phospho-STAT3 in response to IL-10 (but not in response to IL-6). This alteration was NOT caused by reduction of IL-10 receptor expression, nor induction of SOCS-1 or 3. Instead, microarray analysis showed that IFN-b increases STAT1 levels causing a reversal of the STAT1/STAT3 protein ratio in T cells, suggesting a novel role for this transcription factor. In agreement, STAT1-KO T cells exposed to IFN-b did not show any defect in IL-10 signaling. In diabetes-prone NOD mice we discovered a persistent reduction of IL-10 signaling in T cells of pancreatic and mesenteric lymph nodes (but not in T cells of other lymphoid tissues), correlating with the reported aberrant and localized accumulation of TI-IFNs in these mice. Early treatment of NOD mice with an IFNRA blocking antibody (that delays the onset and reduces the incidence of T1D) showed a clear restoration of IL-10 signaling. Overall, these data reveal a previously unknown molecular interplay between IL-10 and TI-IFNs that, if thoroughly elucidated, could reveal a novel target of intervention to enhance the efficacy of T1D immunotherapies." @default.
- W4313359061 created "2023-01-06" @default.
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- W4313359061 date "2019-05-01" @default.
- W4313359061 modified "2023-09-28" @default.
- W4313359061 title "Type-1 interferons inhibition of Interleukin-10 signaling in T cells in Type 1 Diabetes development" @default.
- W4313359061 doi "https://doi.org/10.4049/jimmunol.202.supp.116.8" @default.
- W4313359061 hasPublicationYear "2019" @default.
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