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- W4313359072 abstract "Abstract Asthma constitutes a spectrum of conditions that affect a substantial proportion of the population in developed countries. A large segment of asthmatics are characterized by an immunologic type 2 allergic profile. A preponderance of conventional and biologically-based therapies are available to treat these subjects. However, a small minority of individuals clinically classified as severe asthmatics (SA), are highly refractory to treatment and account for a significantly disproportionate share of the clinical and economic impact of the asthma condition as a whole. In order to better define the immune response in SA with the ultimate goal of developing novel therapeutic modalities, we analyzed bronchoalveolar lavage (BAL) cells from a cohort of SA, mild to moderate asthmatics (M/M), and healthy controls by mass cytometry (CyTOF). Unbiased bioinformatic assessment revealed 34 clusters of BAL cells with assignment of subjects to one of four groupings by principal component analysis (PCA). The majority of SA (78.9%) fell into two of these groups and constituted 65.2% of their makeup, with M/M representing the remaining 34.8%. Similarly, analysis of airway bronchial epithelial cells (BECs) by RNA sequencing (RNASeq) revealed three subject groups with SA falling largely into one of these. Synthesis of CyTOF and RNASeq data in the context of relevant clinical parameters resulted in a combined profile for each subject, which was able to distinguish those with the most severe disease. Our approach demonstrates that an unbiased, multifactorial assessment of immune and epithelial profiles can predict asthma severity, but may also reveal mechanism-based clues for targeted, personalized therapeutic intervention in severe asthmatics." @default.
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- W4313359072 date "2019-05-01" @default.
- W4313359072 modified "2023-09-26" @default.
- W4313359072 title "Combined immune and airway epithelial cell profiles define asthma severity phenotypes" @default.
- W4313359072 doi "https://doi.org/10.4049/jimmunol.202.supp.119.1" @default.
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