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- W4313359148 abstract "Abstract Acute and chronic psychological stress are known to trigger components of the inflammatory system resulting in increased levels of pro-inflammatory cytokines (i.e., IL-1β, IL-6 and TNFα). Stress can also result in the activation of the coagulation and fibrinolytic systems via the sympathoadrenal medullary system, resulting in net hypercoagulability. The aim of this study was to investigate the effects of acute stress on the salivary levels of a key component of the fibrinolytic system, urokinase plasminogen activated receptor (uPAR) and determine the relationship with changes in pro- and anti-inflammatory cytokines. Healthy subjects, ages 18–40 (74% female), were randomly assigned to complete a modified Trier Social Stress Test (n = 44) or to recall an angry autobiographical memory (n = 46). Saliva samples, taken at baseline and 60 min post-stress, were used to measure levels of cytokines and uPAR. Acute stress resulted in a significant increase in the salivary levels of uPAR (p<0.0001) when comparing baseline (median [IQR]: 1.83 [2.31] ng/mL) to post-stress samples (2.57 [2.87] ng/mL). The magnitude of the increase in uPAR levels was similar to those for pro- and anti-inflammatory mediators. There were no significant differences between the two types of stressors. There was moderate to moderate-high correlations with the salivary levels of pro-inflammatory, but not anti-inflammatory cytokines, particularly in the post-stressor samples. These results suggest that components of the fibrinolytic system may also influenced by acute stress, prompting further research into understanding their physiological implications. In addition, uPAR levels in saliva may have potential application as stress biomarkers in saliva." @default.
- W4313359148 created "2023-01-06" @default.
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- W4313359148 date "2018-05-01" @default.
- W4313359148 modified "2023-10-17" @default.
- W4313359148 title "Increased salivary levels of Urokinase Plasminogen Activator Receptor (uPAR) are induced by acute stress and correlate with levels of pro-inflammatory cytokines" @default.
- W4313359148 doi "https://doi.org/10.4049/jimmunol.200.supp.42.27" @default.
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