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- W4313359156 abstract "Abstract Dysregulated T cell responses cause inflammation and autoimmune diseases. These conditions are managed with agents to limit and down-modulate the diverse cellular processes that control T cell activation. Cellular metabolism is a primary regulator of immune cell fate and function. T cell activation is correlated with metabolic shifts, especially in glycolysis, providing increased metabolic flux to support high rates of cellular proliferation. In this study we evaluated the impact of immunosuppressive compounds on the magnitude and kinetics of early anti-CD3/CD28 mediated T cell activation from a metabolic perspective. We employed compounds with divergent inhibitory mechanisms in order to understand the relationship of specific inhibitory pathways and metabolic function. Using an Agilent Seahorse XF Analyzer, T cells were activated in situ and activation was quantified in real time using proton efflux rate (PER) as a measure of glycolysis. Here, we report that anti-CD3/CD28-mediated T cell activation was suppressed when cells were pretreated with 20 μM prednisone. In contrast, activation was increased in the presence of 20 μM cyclosporin A. In non-activated cells, neither compound had a measurable effect on metabolism within 30 min of treatment. These data show a correlation in timing of suppression with the context of the drugs action. Future studies will utilize additional inhibitory pathway modulators to further examine the mechanisms of T cell activation in the context of immunosuppression." @default.
- W4313359156 created "2023-01-06" @default.
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- W4313359156 date "2019-05-01" @default.
- W4313359156 modified "2023-09-26" @default.
- W4313359156 title "Differential modulation of T cell activation" @default.
- W4313359156 doi "https://doi.org/10.4049/jimmunol.202.supp.56.16" @default.
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