Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313359185> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4313359185 endingPage "105.3" @default.
- W4313359185 startingPage "105.3" @default.
- W4313359185 abstract "Abstract Interleukin 9 (IL-9) is a pleiotropic cytokine that plays a central role in immunological disorders. Extensive work has been done to describe the Il9 gene locus and its transcriptional regulation in Th9 and other T cell subsets. Some innate immune cells, such as mast cells and basophils, can also produce a substantial amount of IL-9 in an inflammatory milieu. However, very little is known about how the Il9 gene is regulated in these cells. In this study, we show for the first time that IL-33, and not IgE cross linking, induces IL-9 production in mast cells and basophils and that this is an IL-3 dependent effect. Using the CRISPR-Cas9-mediated deletion approach, we show that IL-9 production in mast cells and basophils is dependent on a conserved non-coding sequence -25 kb (CNS-25) upstream of the IL-9 promoter. Our results show that the CNS-25 region is important for mast cell and basophil IL-9 production in vitro and in vivo. ChIP assays show that the CNS-25 can bind multiple transcription factors at a higher magnitude than the Il9 promoter. Additionally, this region has high chromatin remodeling and p300, an acetyl transferase, binding in mast cells. We show that p300 is essential for IL-33 induced IL-9 production in mast cells and basophils. Taken together, our data define a mechanism for Il9 gene regulation orchestrated by IL-33 and IL-3 signaling in mast cells and basophils." @default.
- W4313359185 created "2023-01-06" @default.
- W4313359185 creator A5030785720 @default.
- W4313359185 creator A5074459288 @default.
- W4313359185 creator A5081400906 @default.
- W4313359185 date "2018-05-01" @default.
- W4313359185 modified "2023-09-27" @default.
- W4313359185 title "Identification of an <i>Il9</i> gene locus regulatory element in mast cells and basophils" @default.
- W4313359185 doi "https://doi.org/10.4049/jimmunol.200.supp.105.3" @default.
- W4313359185 hasPublicationYear "2018" @default.
- W4313359185 type Work @default.
- W4313359185 citedByCount "0" @default.
- W4313359185 crossrefType "journal-article" @default.
- W4313359185 hasAuthorship W4313359185A5030785720 @default.
- W4313359185 hasAuthorship W4313359185A5074459288 @default.
- W4313359185 hasAuthorship W4313359185A5081400906 @default.
- W4313359185 hasConcept C104317684 @default.
- W4313359185 hasConcept C1122143 @default.
- W4313359185 hasConcept C122862929 @default.
- W4313359185 hasConcept C134018914 @default.
- W4313359185 hasConcept C141105273 @default.
- W4313359185 hasConcept C159654299 @default.
- W4313359185 hasConcept C181901479 @default.
- W4313359185 hasConcept C203014093 @default.
- W4313359185 hasConcept C2777456892 @default.
- W4313359185 hasConcept C2778690821 @default.
- W4313359185 hasConcept C2779726688 @default.
- W4313359185 hasConcept C2909016868 @default.
- W4313359185 hasConcept C54355233 @default.
- W4313359185 hasConcept C74172505 @default.
- W4313359185 hasConcept C86339819 @default.
- W4313359185 hasConcept C86803240 @default.
- W4313359185 hasConcept C8891405 @default.
- W4313359185 hasConcept C95444343 @default.
- W4313359185 hasConceptScore W4313359185C104317684 @default.
- W4313359185 hasConceptScore W4313359185C1122143 @default.
- W4313359185 hasConceptScore W4313359185C122862929 @default.
- W4313359185 hasConceptScore W4313359185C134018914 @default.
- W4313359185 hasConceptScore W4313359185C141105273 @default.
- W4313359185 hasConceptScore W4313359185C159654299 @default.
- W4313359185 hasConceptScore W4313359185C181901479 @default.
- W4313359185 hasConceptScore W4313359185C203014093 @default.
- W4313359185 hasConceptScore W4313359185C2777456892 @default.
- W4313359185 hasConceptScore W4313359185C2778690821 @default.
- W4313359185 hasConceptScore W4313359185C2779726688 @default.
- W4313359185 hasConceptScore W4313359185C2909016868 @default.
- W4313359185 hasConceptScore W4313359185C54355233 @default.
- W4313359185 hasConceptScore W4313359185C74172505 @default.
- W4313359185 hasConceptScore W4313359185C86339819 @default.
- W4313359185 hasConceptScore W4313359185C86803240 @default.
- W4313359185 hasConceptScore W4313359185C8891405 @default.
- W4313359185 hasConceptScore W4313359185C95444343 @default.
- W4313359185 hasIssue "1_Supplement" @default.
- W4313359185 hasLocation W43133591851 @default.
- W4313359185 hasOpenAccess W4313359185 @default.
- W4313359185 hasPrimaryLocation W43133591851 @default.
- W4313359185 hasRelatedWork W13881838 @default.
- W4313359185 hasRelatedWork W1480296054 @default.
- W4313359185 hasRelatedWork W2069939254 @default.
- W4313359185 hasRelatedWork W2161937009 @default.
- W4313359185 hasRelatedWork W2164396254 @default.
- W4313359185 hasRelatedWork W2327036362 @default.
- W4313359185 hasRelatedWork W2419110071 @default.
- W4313359185 hasRelatedWork W2425842178 @default.
- W4313359185 hasRelatedWork W2727727099 @default.
- W4313359185 hasRelatedWork W629677220 @default.
- W4313359185 hasVolume "200" @default.
- W4313359185 isParatext "false" @default.
- W4313359185 isRetracted "false" @default.
- W4313359185 workType "article" @default.