Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313359238> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4313359238 endingPage "48.12" @default.
- W4313359238 startingPage "48.12" @default.
- W4313359238 abstract "Abstract The gammaherpesviruses (gHV) which include human Epstein Barr virus (EBV), Kaposi’s sarcoma-associated herpesvirus (KSHV) and murine gammaherpesvirus 68 (MHV68) are associated with B cell malignancy including Burkitt lymphoma. All herpesvirus encode a viral homolog of the mammalian Uracil DNA-glycosylase (UNG) gene. In B cells, mammalian UNG plays a critical role in the antibody diversification processes of class switch recombination (CSR) and somatic hypermutation (SHM). UNG processes U:G mismatches created by activation-induced cytidine deaminase (AID) in an error-prone fashion to accomplish CSR and SHM. During primary infection, gHV expands in the germinal center B cells which actively express AID and undergo CSR and SHM. However, the function of viral UNG (vUNG) on viral pathogenesis and host genome integrity during the mutagenic germinal center reaction is an open question. Using a MHV68 mouse infection model we find that germinal center cells are the major viral targets during acute infection. Analysis of infected cells demonstrates significant overlap of vUNG and AID expression. Using a cell based hypermutation reporter assay, we find that host UNG supports error-prone repair and mutagenesis while vUNG results in only high-fidelity error-free repair of AID lesions. In vitro biochemical characterization finds several differences between vUNG and host UNG, including the ability of vUNG to bind abasic sites. These results demonstrate a differential ability of UNGs to support error-prone versus error-free repair. The finding that vUNG is expressed in germinal center cells suggest a novel mechanism whereby gammaherpesvirus can affect antibody diversification and B lymphocyte function." @default.
- W4313359238 created "2023-01-06" @default.
- W4313359238 creator A5005094349 @default.
- W4313359238 creator A5009748553 @default.
- W4313359238 creator A5011387709 @default.
- W4313359238 creator A5018527689 @default.
- W4313359238 creator A5056445815 @default.
- W4313359238 creator A5067565454 @default.
- W4313359238 creator A5068250768 @default.
- W4313359238 date "2018-05-01" @default.
- W4313359238 modified "2023-09-23" @default.
- W4313359238 title "Uracil DNA Glycosylase of Gammaherpesvirus alters somatic hypermutation through error-free DNA repair" @default.
- W4313359238 doi "https://doi.org/10.4049/jimmunol.200.supp.48.12" @default.
- W4313359238 hasPublicationYear "2018" @default.
- W4313359238 type Work @default.
- W4313359238 citedByCount "0" @default.
- W4313359238 crossrefType "journal-article" @default.
- W4313359238 hasAuthorship W4313359238A5005094349 @default.
- W4313359238 hasAuthorship W4313359238A5009748553 @default.
- W4313359238 hasAuthorship W4313359238A5011387709 @default.
- W4313359238 hasAuthorship W4313359238A5018527689 @default.
- W4313359238 hasAuthorship W4313359238A5056445815 @default.
- W4313359238 hasAuthorship W4313359238A5067565454 @default.
- W4313359238 hasAuthorship W4313359238A5068250768 @default.
- W4313359238 hasConcept C104317684 @default.
- W4313359238 hasConcept C128526571 @default.
- W4313359238 hasConcept C134935766 @default.
- W4313359238 hasConcept C137756551 @default.
- W4313359238 hasConcept C159047783 @default.
- W4313359238 hasConcept C159654299 @default.
- W4313359238 hasConcept C187206112 @default.
- W4313359238 hasConcept C192396546 @default.
- W4313359238 hasConcept C2522874641 @default.
- W4313359238 hasConcept C27082348 @default.
- W4313359238 hasConcept C2776985229 @default.
- W4313359238 hasConcept C2778453870 @default.
- W4313359238 hasConcept C2778711568 @default.
- W4313359238 hasConcept C2781196997 @default.
- W4313359238 hasConcept C2781375147 @default.
- W4313359238 hasConcept C54355233 @default.
- W4313359238 hasConcept C86803240 @default.
- W4313359238 hasConcept C96926380 @default.
- W4313359238 hasConceptScore W4313359238C104317684 @default.
- W4313359238 hasConceptScore W4313359238C128526571 @default.
- W4313359238 hasConceptScore W4313359238C134935766 @default.
- W4313359238 hasConceptScore W4313359238C137756551 @default.
- W4313359238 hasConceptScore W4313359238C159047783 @default.
- W4313359238 hasConceptScore W4313359238C159654299 @default.
- W4313359238 hasConceptScore W4313359238C187206112 @default.
- W4313359238 hasConceptScore W4313359238C192396546 @default.
- W4313359238 hasConceptScore W4313359238C2522874641 @default.
- W4313359238 hasConceptScore W4313359238C27082348 @default.
- W4313359238 hasConceptScore W4313359238C2776985229 @default.
- W4313359238 hasConceptScore W4313359238C2778453870 @default.
- W4313359238 hasConceptScore W4313359238C2778711568 @default.
- W4313359238 hasConceptScore W4313359238C2781196997 @default.
- W4313359238 hasConceptScore W4313359238C2781375147 @default.
- W4313359238 hasConceptScore W4313359238C54355233 @default.
- W4313359238 hasConceptScore W4313359238C86803240 @default.
- W4313359238 hasConceptScore W4313359238C96926380 @default.
- W4313359238 hasIssue "1_Supplement" @default.
- W4313359238 hasLocation W43133592381 @default.
- W4313359238 hasOpenAccess W4313359238 @default.
- W4313359238 hasPrimaryLocation W43133592381 @default.
- W4313359238 hasRelatedWork W2057782162 @default.
- W4313359238 hasRelatedWork W2062962362 @default.
- W4313359238 hasRelatedWork W2079502910 @default.
- W4313359238 hasRelatedWork W2095309707 @default.
- W4313359238 hasRelatedWork W2095662446 @default.
- W4313359238 hasRelatedWork W2112662100 @default.
- W4313359238 hasRelatedWork W2528436478 @default.
- W4313359238 hasRelatedWork W2557070038 @default.
- W4313359238 hasRelatedWork W3217383311 @default.
- W4313359238 hasRelatedWork W3217630413 @default.
- W4313359238 hasVolume "200" @default.
- W4313359238 isParatext "false" @default.
- W4313359238 isRetracted "false" @default.
- W4313359238 workType "article" @default.