Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313359369> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4313359369 endingPage "48.16" @default.
- W4313359369 startingPage "48.16" @default.
- W4313359369 abstract "Abstract Cell division is required for the initiation of B cell differentiation, the regulation of isotype class switching, and ultimately entry of cells into the plasma cell (PC) lineage. Division coupled changes in the expression of transcription factors, such as interferon regulatory factor-4 (IRF4), that coordinate the PC transcriptional program also occur; however, little is known regarding how these factors coordinate cell division and exit from the cell cycle after differentiation. To begin to address this gap in knowledge, we assessed the cell division kinetics of wildtype (WT) B cells responding to the T cell independent antigen lipopolysaccharide (LPS). Interestingly, we found that WT B cells undergo at least 8 divisions before differentiating into PCs. Computational modeling of division rates over time defined a proliferative burst between 48 and 60 hours after LPS injection that is characterized by a rapid increase in the rate of cell division. IRF4-deficient B cells divided but failed to undergo the proliferative burst resulting in fewer activated B cells. Indeed, IRF4 is expressed at low levels during these divisions before being upregulated in post-mitotic CD138+ PCs after 8 divisions. Notably, while more than 40% of WT B cells reached division 8+ by 72 hours, IRF4-null B cells appeared to be stalled at divisions 2–5. Taken together, these data suggest that IRF4 regulates the rate of cellular proliferation during B cell differentiation that occurs around divisions 2–5 and that this role may be concentration-dependent." @default.
- W4313359369 created "2023-01-06" @default.
- W4313359369 creator A5022806169 @default.
- W4313359369 creator A5068787613 @default.
- W4313359369 creator A5070734398 @default.
- W4313359369 date "2018-05-01" @default.
- W4313359369 modified "2023-09-28" @default.
- W4313359369 title "IRF4 regulates the rate of cell cycle during B cell differentiation." @default.
- W4313359369 doi "https://doi.org/10.4049/jimmunol.200.supp.48.16" @default.
- W4313359369 hasPublicationYear "2018" @default.
- W4313359369 type Work @default.
- W4313359369 citedByCount "0" @default.
- W4313359369 crossrefType "journal-article" @default.
- W4313359369 hasAuthorship W4313359369A5022806169 @default.
- W4313359369 hasAuthorship W4313359369A5068787613 @default.
- W4313359369 hasAuthorship W4313359369A5070734398 @default.
- W4313359369 hasConcept C104317684 @default.
- W4313359369 hasConcept C12652872 @default.
- W4313359369 hasConcept C148738053 @default.
- W4313359369 hasConcept C1491633281 @default.
- W4313359369 hasConcept C159654299 @default.
- W4313359369 hasConcept C200180986 @default.
- W4313359369 hasConcept C203014093 @default.
- W4313359369 hasConcept C2776090121 @default.
- W4313359369 hasConcept C2778453870 @default.
- W4313359369 hasConcept C29537977 @default.
- W4313359369 hasConcept C54355233 @default.
- W4313359369 hasConcept C62112901 @default.
- W4313359369 hasConcept C67662055 @default.
- W4313359369 hasConcept C85813293 @default.
- W4313359369 hasConcept C86339819 @default.
- W4313359369 hasConcept C86803240 @default.
- W4313359369 hasConcept C8891405 @default.
- W4313359369 hasConcept C93304396 @default.
- W4313359369 hasConcept C95444343 @default.
- W4313359369 hasConceptScore W4313359369C104317684 @default.
- W4313359369 hasConceptScore W4313359369C12652872 @default.
- W4313359369 hasConceptScore W4313359369C148738053 @default.
- W4313359369 hasConceptScore W4313359369C1491633281 @default.
- W4313359369 hasConceptScore W4313359369C159654299 @default.
- W4313359369 hasConceptScore W4313359369C200180986 @default.
- W4313359369 hasConceptScore W4313359369C203014093 @default.
- W4313359369 hasConceptScore W4313359369C2776090121 @default.
- W4313359369 hasConceptScore W4313359369C2778453870 @default.
- W4313359369 hasConceptScore W4313359369C29537977 @default.
- W4313359369 hasConceptScore W4313359369C54355233 @default.
- W4313359369 hasConceptScore W4313359369C62112901 @default.
- W4313359369 hasConceptScore W4313359369C67662055 @default.
- W4313359369 hasConceptScore W4313359369C85813293 @default.
- W4313359369 hasConceptScore W4313359369C86339819 @default.
- W4313359369 hasConceptScore W4313359369C86803240 @default.
- W4313359369 hasConceptScore W4313359369C8891405 @default.
- W4313359369 hasConceptScore W4313359369C93304396 @default.
- W4313359369 hasConceptScore W4313359369C95444343 @default.
- W4313359369 hasIssue "1_Supplement" @default.
- W4313359369 hasLocation W43133593691 @default.
- W4313359369 hasOpenAccess W4313359369 @default.
- W4313359369 hasPrimaryLocation W43133593691 @default.
- W4313359369 hasRelatedWork W1999714242 @default.
- W4313359369 hasRelatedWork W2054608659 @default.
- W4313359369 hasRelatedWork W2059386627 @default.
- W4313359369 hasRelatedWork W2062057385 @default.
- W4313359369 hasRelatedWork W2102962755 @default.
- W4313359369 hasRelatedWork W2106422137 @default.
- W4313359369 hasRelatedWork W2146508653 @default.
- W4313359369 hasRelatedWork W2278670241 @default.
- W4313359369 hasRelatedWork W2363880822 @default.
- W4313359369 hasRelatedWork W2944164074 @default.
- W4313359369 hasVolume "200" @default.
- W4313359369 isParatext "false" @default.
- W4313359369 isRetracted "false" @default.
- W4313359369 workType "article" @default.