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- W4313359377 abstract "Abstract The CD300 molecules are a family of immunoglobulin-like molecules that have immune regulatory functions. It includes both inhibitory and triggering members, which are highly conserved within the family as well as across species. CD300e, the most restricted member of the family, is expressed in low amounts in most of tissue, whereas its expression is upregulated in different cancers, such as, colorectal, stomach, liver, ovarian and pancreatic cancer. CD300e is highly expressed on CD14+ monocytes. Differentiation of monocytes into dendritic cells (DCs) and macrophages down regulated their CD300e expression. As no monoclonal antibodies are available yet to mouse CD300e, we generated a CD300e knock-out (KO) mouse as an alternative approach to study its biology. We have characterized the changes in immune cells populations resulting from CD300e deletion. The CD300eKO mice are in general fit and reproductively healthy. Mice with CD300e deficiency has a significantly reduction in their circulating leukocytes compared to wild type mice. Hematopoietic stem cells from CD300eKO mice were capable of differentiating in vitro into DC or macrophages with normal antigen uptake and T cell stimulatory capacity. We are using CD300eKO mice to elucidate CD300e function by further testing a variety of functions in monocytic cells." @default.
- W4313359377 created "2023-01-06" @default.
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- W4313359377 date "2018-05-01" @default.
- W4313359377 modified "2023-09-23" @default.
- W4313359377 title "Characterizing the function of the CD300e immunoregulatory molecule." @default.
- W4313359377 doi "https://doi.org/10.4049/jimmunol.200.supp.109.1" @default.
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