Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313359481> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4313359481 endingPage "49.18" @default.
- W4313359481 startingPage "49.18" @default.
- W4313359481 abstract "Abstract Natural Killer (NK) cells as minor subsets of peripheral blood lymphocytes (PBL) are innate in nature to clear invading pathogens and tumor cells. Small rodent species to nonhuman primates and humans, immune systems consist of a spectrum of NK cell subsets with phenotype and functional diversity. This study examined NK cell subsets and expression of NKp46 in squirrel and owl monkeys, which are both New World primate species. Squirrel and owl monkeys are recommended by the World Health Organization as excellent experimental models for studies of malaria infection due to their susceptibility to some of the same strains that cause disease in humans and endemic viruses that are analogues of opportunistic human viruses. NK cells were identified from CD3 negative lymphocytes and sub-phenotyped by CD16 and CD8 expression, to classify CD8+ and CD8− NK cells and absolute numbers in peripheral blood were compared. Analysis of expression of NCR (Natural Cytotoxicity Receptors) proteins, NKp30 and NKp46 showed that NK cells from NHP had preferential expression of NKp46 over NKp30 and expression is mostly restricted to subset of CD8+ NK cells. Peripheral blood lymphocytes, enriched based on NKp46 expression, were further phenotyped as classic CD3−CD16+CD8+NK cells. Functional analysis of enriched cells was focused to verify whether subsets differ in cytolitic and/or “innate” in nature and to correlate with NCR protein expression. Enriched NK cells were co-cultured for stimulation with standard target cells including tumor cells and analyzed for cytokine production. The potential plasticity of peripheral blood NK cells in NHP based on steady state and/or inflammatory/pathogenic status of species will be analyzed and discussed." @default.
- W4313359481 created "2023-01-06" @default.
- W4313359481 creator A5033590404 @default.
- W4313359481 creator A5038887071 @default.
- W4313359481 creator A5039297192 @default.
- W4313359481 creator A5040827308 @default.
- W4313359481 creator A5066578479 @default.
- W4313359481 date "2018-05-01" @default.
- W4313359481 modified "2023-09-29" @default.
- W4313359481 title "Identification and functional analysis of NKp46+ natural killer cells from peripheral blood of squirrel (<i>Saimiri sps</i>.) and owl monkey (<i>Aotus sps</i>.)" @default.
- W4313359481 doi "https://doi.org/10.4049/jimmunol.200.supp.49.18" @default.
- W4313359481 hasPublicationYear "2018" @default.
- W4313359481 type Work @default.
- W4313359481 citedByCount "0" @default.
- W4313359481 crossrefType "journal-article" @default.
- W4313359481 hasAuthorship W4313359481A5033590404 @default.
- W4313359481 hasAuthorship W4313359481A5038887071 @default.
- W4313359481 hasAuthorship W4313359481A5039297192 @default.
- W4313359481 hasAuthorship W4313359481A5040827308 @default.
- W4313359481 hasAuthorship W4313359481A5066578479 @default.
- W4313359481 hasConcept C114684123 @default.
- W4313359481 hasConcept C129374314 @default.
- W4313359481 hasConcept C136449434 @default.
- W4313359481 hasConcept C154317977 @default.
- W4313359481 hasConcept C167672396 @default.
- W4313359481 hasConcept C196166836 @default.
- W4313359481 hasConcept C202751555 @default.
- W4313359481 hasConcept C203014093 @default.
- W4313359481 hasConcept C2778102761 @default.
- W4313359481 hasConcept C2781462264 @default.
- W4313359481 hasConcept C54355233 @default.
- W4313359481 hasConcept C553184892 @default.
- W4313359481 hasConcept C86803240 @default.
- W4313359481 hasConcept C8891405 @default.
- W4313359481 hasConcept C95444343 @default.
- W4313359481 hasConceptScore W4313359481C114684123 @default.
- W4313359481 hasConceptScore W4313359481C129374314 @default.
- W4313359481 hasConceptScore W4313359481C136449434 @default.
- W4313359481 hasConceptScore W4313359481C154317977 @default.
- W4313359481 hasConceptScore W4313359481C167672396 @default.
- W4313359481 hasConceptScore W4313359481C196166836 @default.
- W4313359481 hasConceptScore W4313359481C202751555 @default.
- W4313359481 hasConceptScore W4313359481C203014093 @default.
- W4313359481 hasConceptScore W4313359481C2778102761 @default.
- W4313359481 hasConceptScore W4313359481C2781462264 @default.
- W4313359481 hasConceptScore W4313359481C54355233 @default.
- W4313359481 hasConceptScore W4313359481C553184892 @default.
- W4313359481 hasConceptScore W4313359481C86803240 @default.
- W4313359481 hasConceptScore W4313359481C8891405 @default.
- W4313359481 hasConceptScore W4313359481C95444343 @default.
- W4313359481 hasIssue "1_Supplement" @default.
- W4313359481 hasLocation W43133594811 @default.
- W4313359481 hasOpenAccess W4313359481 @default.
- W4313359481 hasPrimaryLocation W43133594811 @default.
- W4313359481 hasRelatedWork W119517883 @default.
- W4313359481 hasRelatedWork W1196912039 @default.
- W4313359481 hasRelatedWork W145559749 @default.
- W4313359481 hasRelatedWork W1975713294 @default.
- W4313359481 hasRelatedWork W2018916009 @default.
- W4313359481 hasRelatedWork W2026543809 @default.
- W4313359481 hasRelatedWork W2051727352 @default.
- W4313359481 hasRelatedWork W2059645795 @default.
- W4313359481 hasRelatedWork W2079925062 @default.
- W4313359481 hasRelatedWork W2128373043 @default.
- W4313359481 hasVolume "200" @default.
- W4313359481 isParatext "false" @default.
- W4313359481 isRetracted "false" @default.
- W4313359481 workType "article" @default.