Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313359492> ?p ?o ?g. }
Showing items 1 to 52 of
52
with 100 items per page.
- W4313359492 endingPage "121.18" @default.
- W4313359492 startingPage "121.18" @default.
- W4313359492 abstract "Abstract Interleukin 35 (IL-35) cytokine is comprised of two subunits, IL-12p35 and Ebi3 and both subunits are thought to be required for the expansion of regulatory B cells (Bregs) that suppress autoimmune diseases. Although use of IL-35 to produce Breg cells has substantial promise for the development of cell therapy against autoimmune and neurodegenerative diseases, some significant challenges have yet to be overcome before it can brought to the clinic. For example, the association of the IL-12p35 and Ebi3 subunits is not strong and readily dissociates, making it difficult to ascertain the effective dose of the bioactive IL-12p35:Ebi3 heterodimer administered or required to ameliorate disease. In this study, we show that IL-12p35 alone has anti-inflammatory properties that recapitulated essential therapeutic functions of the heterodimeric IL-35 cytokine. IL-12p35 induced the expansion of Breg cells in vivo and adoptive transfer of ex-vivo-generated Breg cells using IL-12p35 suppressed inflammation and the development of pathology in mouse models of experimental autoimmune uveitis (EAU) or encephalomyedlitis (EAE). The inflammatory immune cells penetrated the retina, brain and spinal cord in the untreated mice whereas these traits were far more reduced in the IL-12p35-treated mice. In conclusion, the recapitulation of essential immunosuppressive activities of IL-35 by IL-12p35, indicates that IL-12p35 may be utilized for in vivo expansion of Breg cells and autologous Breg cell immunotherapy. These and our unpublished observations suggest that IL-12 single chain proteins may constitute a new generation of therapeutic cytokines that can be exploited to treat autoimmune and neurodegenerative diseases." @default.
- W4313359492 created "2023-01-06" @default.
- W4313359492 creator A5004732672 @default.
- W4313359492 creator A5015473253 @default.
- W4313359492 creator A5029106350 @default.
- W4313359492 creator A5037496831 @default.
- W4313359492 creator A5061606279 @default.
- W4313359492 creator A5063223142 @default.
- W4313359492 creator A5087901599 @default.
- W4313359492 creator A5088634575 @default.
- W4313359492 date "2018-05-01" @default.
- W4313359492 modified "2023-09-25" @default.
- W4313359492 title "IL-12p35 suppresses encephalitis and uveitis in mice" @default.
- W4313359492 doi "https://doi.org/10.4049/jimmunol.200.supp.121.18" @default.
- W4313359492 hasPublicationYear "2018" @default.
- W4313359492 type Work @default.
- W4313359492 citedByCount "0" @default.
- W4313359492 crossrefType "journal-article" @default.
- W4313359492 hasAuthorship W4313359492A5004732672 @default.
- W4313359492 hasAuthorship W4313359492A5015473253 @default.
- W4313359492 hasAuthorship W4313359492A5029106350 @default.
- W4313359492 hasAuthorship W4313359492A5037496831 @default.
- W4313359492 hasAuthorship W4313359492A5061606279 @default.
- W4313359492 hasAuthorship W4313359492A5063223142 @default.
- W4313359492 hasAuthorship W4313359492A5087901599 @default.
- W4313359492 hasAuthorship W4313359492A5088634575 @default.
- W4313359492 hasConcept C203014093 @default.
- W4313359492 hasConcept C2778690821 @default.
- W4313359492 hasConcept C86803240 @default.
- W4313359492 hasConceptScore W4313359492C203014093 @default.
- W4313359492 hasConceptScore W4313359492C2778690821 @default.
- W4313359492 hasConceptScore W4313359492C86803240 @default.
- W4313359492 hasIssue "1_Supplement" @default.
- W4313359492 hasLocation W43133594921 @default.
- W4313359492 hasOpenAccess W4313359492 @default.
- W4313359492 hasPrimaryLocation W43133594921 @default.
- W4313359492 hasRelatedWork W1872455594 @default.
- W4313359492 hasRelatedWork W2013060765 @default.
- W4313359492 hasRelatedWork W2023834531 @default.
- W4313359492 hasRelatedWork W2025877143 @default.
- W4313359492 hasRelatedWork W2087976276 @default.
- W4313359492 hasRelatedWork W2127548364 @default.
- W4313359492 hasRelatedWork W2998343095 @default.
- W4313359492 hasRelatedWork W3021115544 @default.
- W4313359492 hasRelatedWork W9581748 @default.
- W4313359492 hasRelatedWork W2187598984 @default.
- W4313359492 hasVolume "200" @default.
- W4313359492 isParatext "false" @default.
- W4313359492 isRetracted "false" @default.
- W4313359492 workType "article" @default.